ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Vesicular GABA Transporter Is Necessary for Transplant-Induced Critical Period Plasticity in Mouse Visual Cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 21 citations in OpenAlex.
- Transplantation of GABAergic Interneuron Progenitors Restores Cortical Circuit Function in an Alzheimer's Disease Mouse Model.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Medial ganglionic eminence transplantation restores inhibition after central visual system brain injury.PNAS nexus · 2025Article
- Integration of Transplanted Interneurons Over a New Period of Ocular Dominance Plasticity in Adult Visual Cortex.bioRxiv : the preprint server for biology · 2025Article
- Stimulus-specific enhancement in mouse visual cortex requires GABA but not VIP-peptide release from VIP interneurons.Journal of neurophysiology · 2024Article
- Host brain environmental influences on transplanted medial ganglionic eminence progenitors.Scientific reports · 2024Article
- Cell therapy for neurological disorders: Progress towards an embryonic medial ganglionic eminence progenitor-based treatment.Frontiers in neuroscience · 2023Review
- Brain-wide reconstruction of inhibitory circuits after traumatic brain injury.Nature communications · 2022Article
- Host interneurons mediate plasticity reactivated by embryonic inhibitory cell transplantation in mouse visual cortex.Nature communications · 2021Article
- The Structural E/I Balance Constrains the Early Development of Cortical Network Activity.Frontiers in cellular neuroscience · 2021Article
- Article
- Using psychophysical performance to predict short-term ocular dominance plasticity in human adults.Journal of vision · 2020Article
- Transplanted Cells Are Essential for the Induction But Not the Expression of Cortical Plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Emerging Roles of Synapse Organizers in the Regulation of Critical Periods.Neural plasticity · 2019Review
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
The maturation of GABAergic inhibitory circuits is necessary for the onset of the critical period for ocular dominance plasticity (ODP) in the postnatal visual cortex (Hensch, 2005; Espinosa and Stryker, 2012). When it is deficient, the critical period does not start. When inhibitory maturation or signaling is precocious, it induces a precocious critical period. Heterochronic transplantation of GABAergic interneuron precursors derived from the medial ganglionic eminence (MGE) can induce a second period of functional plasticity in the visual cortex (Southwell et al., 2010). Although the timing of MGE transplantation-induced plasticity is dictated by the maturation of the transplanted cells, its mechanisms remain largely unknown. Here, we sought to test the effect of blocking vesicular GABA loading and subsequent release by transplanted interneurons on the ability to migrate, integrate, and induce plasticity in the host circuitry. We show that MGE cells taken from male and female donors that lack vesicular GABA transporter (
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