Evidence map›Paper›PMID 30704894›Full record

ArticleInternational journal of hygiene and environmental health2019

Pregnancy phthalate metabolite concentrations and infant birth weight by gradations of maternal glucose tolerance.

Nudrat Noor, Kelly K Ferguson, John D Meeker, Ellen W Seely, Russ Hauser, Tamarra James-Todd, Thomas F McElrath

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of hygiene and environmental health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Nudrat NoorDepartments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Kelly K FergusonEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.
John D MeekerDepartment of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI, 48109, USA.
Ellen W SeelyDivision of Endocrine, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
Russ HauserDepartments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Tamarra James-ToddDepartments of Environmental Health and Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA; Division of Women's Health, Department of Medicine, Connors Center for Women's Health and Gender Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. Electronic address: tjtodd@hsph.harvard.edu.
Thomas F McElrathDivision of Maternal Fetal Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. Electronic address: tmcelrath@bwh.harvard.edu.
Harvard University · USBrigham and Women's Hospital · USNational Institute of Environmental Health Sciences · USUniversity of Michigan–Ann Arbor · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Training Program in Environmental EpidemiologyT32ES007069 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI LADEN, FRANCINE · 1985 to 2024
$13.9M
LIFECODES pregnancy cohortZIAES103321 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI FERGUSON, KELLY · 2016 to 2025
$6.1M
Phthalates, Gestational Diabetes, and Markers of Type 2 Diabetes Risk in WomenR01ES026166 · NIEHS · HARVARD SCHOOL OF PUBLIC HEALTH · PI JAMES-TODD, TAMARRA M · 2016 to 2021
$2.9M
Bisphenol A and Phthalate Exposure in Relation to Fetal Growth and Preterm BirthR01ES018872 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MEEKER, JOHN D. · 2010 to 2014
$2.6M
Blood Pressure in Postmenopausal Women: A GCRC StudyK24RR018613 · NCRR · BRIGHAM AND WOMEN'S HOSPITAL · PI SEELY, ELLEN W · 2003 to 2007
$748k
Intramural NIH HHS ZIA ES103321NCRR NIH HHS K24 RR018613NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R01 ES018872NIEHS NIH HHS R01 ES026166NIEHS NIH HHS T32 ES007069NIEHS NIH HHS ZIA ES103321
6 · The paper itself

Abstract

backgroundHigher birth weight is an important adverse outcome associated with hyperglycemia in pregnancy. Recent studies suggest that phthalate exposure is associated with elevated glucose levels in pregnant women, with implications for higher birth weight in the offspring. No study to date has investigated the association between prenatal phthalate exposure on infant high birth weight accounting for the range of pregnancy glucose levels.

methodsA total of 350 women participating in an ongoing pregnancy cohort had data available on urinary phthalate metabolite concentrations at up to four time points across pregnancy. Urinary phthalate metabolites were averaged across pregnancy and log-transformed, specific gravity-adjusted and analyzed in quartiles. Birth weight was examined continuously (in grams), as well as dichotomized as large for gestational age (>90

resultsApproximately 20% of infants born to women with glucose levels ≥140 mg/dL were large for gestational age. Average mono-ethyl phthalate (MEP) concentrations were higher among women who had glucose levels ≥140 mg/dL (geometric mean 140.9 μg/L; 95% CI: 91.6-216.8); however, higher MEP concentrations were not associated with higher birth weight. When stratified by maternal glucose levels, there was a suggestive association between higher concentrations of mono-(3-carboxypropyl) phthalate (MCPP) and higher birth weight among women with glucose levels ≥140 mg/dL (adj. birth weight: 569.2 g; 95% CI: 14.1, 1178.2).

conclusionsHigher urinary phthalate metabolite concentrations were not significantly associated with higher birth weight. Counter to our hypothesis, women with higher glucose levels and higher urinary phthalate metabolites did not deliver babies with higher birth weight.

Indexed as

Birth WeightMaternal ExposureMaternal-Fetal ExchangeAdultBiological MonitoringBlood GlucoseEnvironmental PollutantsFemaleGlucose Tolerance TestHumansInfant, NewbornMalePhthalic AcidsPregnancyBlood GlucoseEnvironmental PollutantsPhthalic AcidsBirth weightLarge for gestational ageMaternal glucoseMaternal obesityPhthalatesPregnancy

Identifiers

PMID30704894
PMCPMC7193985
OpenAlexW2912392736

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.