ArticleSchizophrenia research2020
Progressive reconfiguration of resting-state brain networks as psychosis develops: Preliminary results from the North American Prodrome Longitudinal Study (NAPLS) consortium.
Article in Schizophrenia research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Right hippocampal volume and attenuated psychotic symptoms distinguish subgroups of youth with common patterns of temporoparietal effective connectivity.Brain structure & function · 2026Article
- Predictors and Moderators of Long-Term Outcome of Persons at Clinical High Risk for Psychosis: Methods and Preliminary Data.Schizophrenia bulletin · 2026Article
- Salience network segregation and symptom profiles in psychosis risk subgroups among youth and early adults.Schizophrenia (Heidelberg, Germany) · 2025Article
- Disruption of functional and structural topological organization in specific subnetwork among patients with classical trigeminal neuralgia: a graph theory-based magnetic resonance imaging study.Brain imaging and behavior · 2025Article
- Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis.Schizophrenia research · 2025Article
- Identifying neurobiological heterogeneity in clinical high-risk psychosis: a data-driven biotyping approach using resting-state functional connectivity.Schizophrenia (Heidelberg, Germany) · 2025Article
- Brain connectomes in youth at risk for serious mental illness: a longitudinal perspective.Brain imaging and behavior · 2025Article
- Unique Functional Neuroimaging Signatures of Genetic Versus Clinical High Risk for Psychosis.Biological psychiatry · 2025Article
- Developmental perspectives on the origins of psychotic disorders: The need for a transdiagnostic approach.Development and psychopathology · 2024Review
- Linking enlarged choroid plexus with plasma analyte and structural phenotypes in clinical high risk for psychosis: A multisite neuroimaging study.Brain, behavior, and immunity · 2024Article
- Functional magnetic resonance imaging in schizophrenia: current evidence, methodological advances, limitations and future directions.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Study of dynamic brain function in irritable bowel syndrome via Hidden Markov Modeling.Frontiers in neuroscience · 2024Article
- Hippocampal Connectivity with the Default Mode Network is Linked to Hippocampal Volume in the Clinical High Risk for Psychosis Syndrome and Healthy Individuals.Clinical psychological science : a journal of the Association for Psychological Science · 2023Article
- Effects of phase encoding direction on test-retest reliability of human functional connectome.NeuroImage · 2023Article
- Evaluating test-retest reliability and sex-/age-related effects on temporal clustering coefficient of dynamic functional brain networks.Human brain mapping · 2023Article
- Cerebellar Functional Dysconnectivity in Drug-Naïve Patients With First-Episode Schizophrenia.Schizophrenia bulletin · 2023Article
- A Review of Potential Neuroimaging Biomarkers of Schizophrenia-Risk.Journal of psychiatry and brain science · 2023Article
- Temporal Stability of Dynamic Default Mode Network Connectivity Negatively Correlates with Suicidality in Major Depressive Disorder.Brain sciences · 2022Article
- A redux of schizophrenia research in 2021.Schizophrenia research · 2022Article
- Cross-paradigm connectivity: reliability, stability, and utility.Brain imaging and behavior · 2021Article
Corrections and comments
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Authors and funding
23 authors.
Funding
Abstract
Mounting evidence has shown disrupted brain network architecture across the psychosis spectrum. However, whether these changes relate to the development of psychosis is unclear. Here, we used graph theoretical analysis to investigate longitudinal changes in resting-state brain networks in samples of 72 subjects at clinical high risk (including 8 cases who converted to full psychosis) and 48 healthy controls drawn from the North American Prodrome Longitudinal Study (NAPLS) consortium. We observed progressive reduction in global efficiency (P = 0.006) and increase in network diversity (P = 0.001) in converters compared with non-converters and controls. More refined analysis separating nodes into nine key brain networks demonstrated that these alterations were primarily driven by progressively diminished local efficiency in the default-mode network (P = 0.004) and progressively enhanced node diversity across all networks (P < 0.05). The change rates of network efficiency and network diversity were significantly correlated (P = 0.003), suggesting these changes may reflect shared neural mechanisms. In addition, change rates of global efficiency and node diversity were significantly correlated with change rate of cortical thinning in the prefrontal cortex in converters (P < 0.03) and could be predicted by visuospatial memory scores at baseline (P < 0.04). These results provide preliminary evidence for longitudinal reconfiguration of resting-state brain networks during psychosis development and suggest that decreased network efficiency, reflecting an increase in path length between nodes, and increased network diversity, reflecting a decrease in the consistency of functional network organization, may be implicated in the progression to full psychosis.
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