ArticleSchizophrenia research2019
Cross-diagnostic analysis of cognitive control in mental illness: Insights from the CNTRACS consortium.
Article in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neuropsychological Performance Among Individuals at Clinical High-Risk for Psychosis vs Putatively Low-Risk Peers With Other Psychopathology: A Systematic Review and Meta-Analysis.Schizophrenia bulletin · 2022Pooled it
- Transdiagnostic and disease-specific abnormalities in the default-mode network hubs in psychiatric disorders: A meta-analysis of resting-state functional imaging studies.European psychiatry : the journal of the Association of European Psychiatrists · 2020Pooled it
- Slower adaptation of control strategies in individuals with high impulsive tendencies.Scientific reports · 2021Trial
- Bipolar Disorder Psychosis Risk Predicts Cue Discrimination on the AX-Continuous Performance Task Paradigm.Bipolar disorders · 2026Article
- Relationships between cognition and symptoms across mood and psychotic disorders.Psychiatry research · 2025Article
- Neural fingerprints of data driven cognitive subtypes across the psychosis spectrum: a B-SNIP study.Translational psychiatry · 2025Article
- Psychometrics of drift-diffusion model parameters derived from the Eriksen flanker task: Reliability and validity in two independent samples.Cognitive, affective & behavioral neuroscience · 2025Article
- Prefrontal Oscillatory Slowing in Early-Course Schizophrenia Is Associated With Worse Cognitive Performance and Negative Symptoms: A Transcranial Magnetic Stimulation-Electroencephalography Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Opaque ontology: neuroimaging classification of ICD-10 diagnostic groups in the UK Biobank.GigaScience · 2025Article
- Clarifying Cognitive Control Deficits in Psychosis via Drift Diffusion Modeling and Attractor Dynamics.Schizophrenia bulletin · 2024Article
- Whole-brain intrinsic functional connectivity predicts symptoms and functioning in early psychosis.Journal of psychiatric research · 2024Article
- Opaque Ontology: Neuroimaging Classification of ICD-10 Diagnostic Groups in the UK Biobank.bioRxiv : the preprint server for biology · 2024Article
- Biomarkers for Cognitive Control, Response Inhibition, Aggressivity, Impulsivity, and Violence.Advances in neurobiology · 2024Review
- Comparing the functional neuroanatomy of proactive and reactive control between patients with schizophrenia and healthy controls.Cognitive, affective & behavioral neuroscience · 2023Article
- An Update on Treatment of Cognitive Impairment Associated with Schizophrenia.Current topics in behavioral neurosciences · 2023Review
- Mechanisms underlying dorsolateral prefrontal cortex contributions to cognitive dysfunction in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Neural Coding of Cognitive Control: The Representational Similarity Analysis Approach.Trends in cognitive sciences · 2021Review
- Acute conceptual disorganization in untreated first-episode psychosis: a combined magnetic resonance spectroscopy and diffusion imaging study of the cingulum.Journal of psychiatry & neuroscience : JPN · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundIn recent years, psychiatry research has increasingly focused on understanding mental illnesses from a cross-diagnostic, dimensional perspective in order to better align their neurocognitive features with underlying neurobiological mechanisms. In this multi-site study, we examined two measures of cognitive control (d-prime context and lapsing rate) during the Dot Probe Expectancy (DPX) version of the AX-Continuous Performance Task in patients with either schizophrenia (SZ), schizoaffective disorder (SZ-A), or Type I bipolar disorder (BD) as well as healthy control (HC) subjects. We hypothesized significantly lower d-prime context and higher lapsing rate in SZ and SZ-A patients and intermediate levels in BD patients relative to HC.
methods72 HC, 84 SZ, 77 SZ-A, and 58 BD patients (ages 18-56) were included in the final study sample.
resultsSignificant main effects of diagnosis were observed on d-prime context (F(3,279) = 9.59, p < 0.001) and lapsing (F(3,279) = 8.08, p < 0.001). A priori linear contrasts suggesting intermediate dysfunction in BD patients were significant (p < 0.001), although post-hoc tests showed the BD group was only significantly different from HC on d-prime context. Group results for d-prime context remained significant after covarying for lapsing rate. Primary behavioral measures were associated with mania and disorganization symptoms as well as everyday functioning.
conclusionsThese findings suggest a continuum of dysfunction in cognitive control (particularly d-prime context) across diagnostic categories in psychiatric illness. These results further suggest that lapsing and d-prime context, while related, make unique contributions towards explaining deficits in cognitive control in these disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.