ArticleBiophysical journal2019
Decoding Calcium Signaling Dynamics during Drosophila Wing Disc Development.
Article in Biophysical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Basal cytoplasmic calcium levels regulate C. elegans germ stem cell proliferation.Development (Cambridge, England) · 2026Article
- Bioelectric state transitions enablebioRxiv : the preprint server for biology · 2026Article
- Mapping the transcriptional diversity of calcium signaling in the mouse and human brain.iScience · 2026Article
- Nematic cell alignment directs calcium waves in an epithelial monolayer.Biophysical journal · 2026Article
- GαCell communication and signaling : CCS · 2025Article
- Nematic cell alignment directs calcium waves.bioRxiv : the preprint server for biology · 2025Article
- Basal cytoplasmic calcium levels regulatebioRxiv : the preprint server for biology · 2025Article
- Dietary amino acids promote glucagon-like hormone release to generate global calcium waves in adipose tissues in Drosophila.Nature communications · 2025Article
- Calcium Imaging in Drosophila.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Calcium wave dynamics in the embryonic mouse gut mesenchyme: impact on smooth muscle differentiation.Communications biology · 2024Article
- Diverse calcium signaling profiles regulate migratory behavior in avascular wound healing and aberrant signal hierarchy occurs early in diabetes.American journal of physiology. Cell physiology · 2024Article
- Piezo regulates epithelial topology and promotes precision in organ size control.Cell reports · 2024Article
- Maintenance of hematopoietic stem cell niche homeostasis requires gap junction-mediated calcium signaling.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- A mathematical model of calcium signals around laser-induced epithelial wounds.Molecular biology of the cell · 2023Article
- Information Theory as an Experimental Tool for Integrating Disparate Biophysical Signaling Modules.International journal of molecular sciences · 2022Article
- Independently paced Ca2+ oscillations in progenitor and differentiated cells in an ex vivo epithelial organ.Journal of cell science · 2022Article
- The evolution of vitamin C biosynthesis and transport in animals.BMC ecology and evolution · 2022Article
- Article
- Mechanisms Underlying Influence of Bioelectricity in Development.Frontiers in cell and developmental biology · 2022Review
- MAPPER: An Open-Source, High-Dimensional Image Analysis Pipeline Unmasks Differential Regulation ofFrontiers in genetics · 2022Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
The robust specification of organ development depends on coordinated cell-cell communication. This process requires signal integration among multiple pathways, relying on second messengers such as calcium ions. Calcium signaling encodes a significant portion of the cellular state by regulating transcription factors, enzymes, and cytoskeletal proteins. However, the relationships between the inputs specifying cell and organ development, calcium signaling dynamics, and final organ morphology are poorly understood. Here, we have designed a quantitative image-analysis pipeline for decoding organ-level calcium signaling. With this pipeline, we extracted spatiotemporal features of calcium signaling dynamics during the development of the Drosophila larval wing disc, a genetic model for organogenesis. We identified specific classes of wing phenotypes that resulted from calcium signaling pathway perturbations, including defects in gross morphology, vein differentiation, and overall size. We found four qualitative classes of calcium signaling activity. These classes can be ordered based on agonist stimulation strength Gαq-mediated signaling. In vivo calcium signaling dynamics depend on both receptor tyrosine kinase/phospholipase C γ and G protein-coupled receptor/phospholipase C β activities. We found that spatially patterned calcium dynamics correlate with known differential growth rates between anterior and posterior compartments. Integrated calcium signaling activity decreases with increasing tissue size, and it responds to morphogenetic perturbations that impact organ growth. Together, these findings define how calcium signaling dynamics integrate upstream inputs to mediate multiple response outputs in developing epithelial organs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.