Evidence map›Paper›PMID 30704471›Full record

ArticleBMC medical genomics2019

A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study.

Xueyan Zhao, Xin Geng, Vinodh Srinivasasainagendra, Ninad Chaudhary, Suzanne Judd, Virginia Wadley, Orlando M Gutiérrez, Henry Wang, Ethan M Lange, Leslie A Lange and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 9 institutions in 2 countries.

Xueyan ZhaoDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
Xin GengBGI-Shenzhen, Shenzhen, 518083, China.
Vinodh SrinivasasainagendraDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
Ninad ChaudharyDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
Suzanne JuddDepartment of Biostatistics, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
Virginia WadleyDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
Orlando M GutiérrezDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
Henry WangDepartment of Emergency Medicine, University of Alabama at Birmingham, Birmingham, AL, 35233, USA.
Ethan M LangeDivision of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Leslie A LangeDivision of Biomedical Informatics and Personalized Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
Daniel WooDepartment of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, 45267, USA.
Frederick W UnverzagtDepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Monika SaffordDivision of General Internal Medicine, Weill Cornell Medical College, Cornell University, New York, NY, 10065, USA.
Mary CushmanDepartment of Medicine and Pathology, Larner College of Medicine at the University of Vermont, Burlington, VT, 05405, USA.
Nita LimdiDepartment of Neurology, University of Alabama at Birmingham, Birmingham, AL, 35294, USA.
Rakale QuarellsCardiovascular Research Institute, Department of Community Health and Preventive Medicine, Morehouse School of Medicine, Atlanta, GA, 30310, USA.
Donna K ArnettCollege of Public Health, University of Kentucky, Lexington, KY, 40506, USA.
Marguerite R IrvinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL, 35233, USA. irvinr@uab.edu.
Degui ZhiSchool of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA. Degui.zhi@uth.tmc.edu.
University of Alabama at Birmingham · USThe University of Texas Health Science Center at Houston · USUniversity of Colorado Anschutz Medical Campus · USCornell University · USIndiana University – Purdue University Indianapolis · USMorehouse School of Medicine · USUniversity of Cincinnati Medical Center · USUniversity of Kentucky · USUniversity of Vermont · US

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
Zevalin Radioimmunotherapy Using a Modified TreatmentM01RR000032 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI RICH, ROBERT R. · 1985 to 2008
$23.6M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Minority Health-GRID Network: A Genomics Resource for Health Disparity ResearchRC4MD005964 · NIMHD · MOREHOUSE SCHOOL OF MEDICINE · PI DAVIS, ROBERT LOWELL, NICKERSON, DEBORAH A · 2010 to 2010
$13.3M
Scalable methods for identity by descentR01HG010086 · NHGRI · YALE UNIVERSITY · PI Shaojie Zhang, Degui Zhi · 2018 to 2026
$4.9M
UAB Statistical Genetics Post-Doctoral Training ProgramT32HL072757 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI TIWARI, HEMANT K. · 2003 to 2016
$3.8M
Patient Oriented Research in Personalized Antithrombotic TherapyK24HL133373 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LIMDI, NITA A · 2016 to 2025
$1.2M
NCRR NIH HHS M01 RR000032NHGRI NIH HHS R01 HG010086NHLBI NIH HHS K24 HL133373NHLBI NIH HHS T32 HL072757NIDDK NIH HHS P30 DK079626NIMHD NIH HHS RC4 MD005964NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

backgroundCardiovascular disease, diabetes, and kidney disease are among the leading causes of death and disability worldwide. However, knowledge of genetic determinants of those diseases in African Americans remains limited.

resultsIn our study, associations between 4956 GWAS catalog reported SNPs and 67 traits were examined among 7726 African Americans from the REasons for Geographic and Racial Differences in Stroke (REGARDS) study, which is focused on identifying factors that increase stroke risk. The prevalent and incident phenotypes studied included inflammation, kidney traits, cardiovascular traits and cognition. Our results validated 29 known associations, of which eight associations were reported for the first time in African Americans.

conclusionOur cross-racial validation of GWAS findings provide additional evidence for the important roles of these loci in the disease process and may help identify genes especially important for future functional validation.

Indexed as

Epidemiologic StudiesGenome-Wide Association StudyObservational Studies as TopicPhenotypePolymorphism, Single NucleotideBlack or African AmericanCohort StudiesFemaleHumansMaleMiddle AgedAfrican AmericansCardiovascular diseaseGeneticsPheWAS

Identifiers

PMID30704471
PMCPMC6357353
OpenAlexW2914390661

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.