Evidence map›Paper›PMID 30704437›Full record

ArticleBMC musculoskeletal disorders2019

Musculoskeletal pains and cardiovascular autonomic function in the general Northern Finnish population.

Petteri Oura, Arto Hautala, Antti Kiviniemi, Juha Auvinen, Katri Puukka, Mikko Tulppo, Heikki Huikuri, Tapio Seppänen, Jaro Karppinen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC musculoskeletal disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Petteri OuraFaculty of Medicine, Center for Life Course Health Research, University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland. petteri.oura@oulu.fi.
Arto HautalaFaculty of Information Technology and Electrical Engineering, Center for Machine Vision and Signal Analysis, University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland.
Antti KiviniemiMedical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland.
Juha AuvinenFaculty of Medicine, Center for Life Course Health Research, University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland.
Katri PuukkaMedical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland.
Mikko TulppoMedical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland.
Heikki HuikuriMedical Research Center Oulu, Oulu University Hospital and University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland.
Tapio SeppänenFaculty of Information Technology and Electrical Engineering, Center for Machine Vision and Signal Analysis, University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland.
Jaro KarppinenFaculty of Medicine, Center for Life Course Health Research, University of Oulu, P.O. Box 5000, FI-90014, Oulu, Finland.
University of Oulu · FIOulu University Hospital · FIFinnish Institute of Occupational Health · FI

Funding

European Regional Development Fund 539/2010 A31592Oulun Yliopisto 24000692Oulu University Hospital 24301140Paulon Säätiö N/ASydäntutkimussäätiö N/ATekes N/A
6 · The paper itself

Abstract

backgroundHeart rate variability (HRV) and baroreflex sensitivity (BRS) measurements provide means for the objective assessment of cardiovascular autonomic function. As previous studies have associated chronic pain with abnormal autonomic function, we aimed to characterize the relationship between the number of musculoskeletal pain sites (NPS), pain intensity, and cardiovascular autonomic function among the population-based Northern Finland Birth Cohort 1966.

methodsAt the age of 46, cohort members self-reported their musculoskeletal pains (enabling the determination of NPS [0-8] and pain intensity [Numerical Rating Scale, NRS, 0-10]) and underwent clinical assessments of cardiovascular autonomic function in seated and standing positions (HRV variables: heart rate [HR] and root mean square of successive differences in beat-to-beat intervals [rMSSD] for the entire cohort; BRS variables: low-frequency systolic blood pressure variability [SBPV] and cross-spectral baroreflex sensitivity [BRS] for those attending the examination in Oulu, Finland). Extensive confounder data were also collected (body mass index, physical activity, smoking, Hopkins Symptom Checklist-25, comorbidities, and medications). The full samples included 4186 and 2031 individuals (HRV and BRS samples, respectively). Three subanalyses focused on individuals with intense and frequent pain, individuals with symptoms of depression and anxiety, and the relationship between pain intensity and autonomic parameters.

resultsLinear regression models showed varying associations between NPS, pain intensity, and cardiovascular autonomic parameters. However, after all adjustments NPS was only associated with one outcome among women (BRS, standing: beta = - 0.015, p = 0.048) and two among men (HR, seated: beta = - 0.902, p = 0.003; HR, standing: beta = - 0.843, p = 0.014). Pain intensity was not associated with any outcome after full adjustments. Significant sex*pain interactions were found in the data.

conclusionsOur data suggest that musculoskeletal pain has, at most, a limited independent association with cardiovascular autonomic function. Future studies should carefully account for the potential confounders and sex interactions that this study revealed.

Indexed as

BaroreflexHeart RateAutonomic Nervous SystemFemaleFinlandHumansMaleMiddle AgedMusculoskeletal PainPain MeasurementProspective StudiesSelf ReportAutonomic nervous systemBaroreflex sensitivityCardiovascular autonomic functionHeart rate variabilityMulti-site painMusculoskeletal pain

Identifiers

PMID30704437
PMCPMC6357438
OpenAlexW2947766272

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.