Evidence map›Paper›PMID 30704154›Full record

ArticleGenes2019

Genetic Analyses Confirm SNPs in HSPA8 and ERBB2 are Associated with Milk Protein Concentration in Chinese Holstein Cattle.

Cong Li, Miao Wang, Wentao Cai, Shuli Liu, Chenghao Zhou, Hongwei Yin, Dongxiao Sun, Shengli Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Polymorphisms ofFoods (Basel, Switzerland) · 2023
    Article
  3. PeerJ · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cong LiShaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology,Northwest A&F University, Yangling, Shaanxi 712100, China. congl@nwafu.edu.cn.ORCID 0000-0003-2588-4781
Miao WangShaanxi Key Laboratory of Molecular Biology for Agriculture, College of Animal Science and Technology,Northwest A&F University, Yangling, Shaanxi 712100, China. wangmiao9254@gmail.com.
Wentao CaiDepartment of Animal Genetics and Breeding, College of Animal Science and Technology, Key Laboratoryof Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory for AnimalBreeding, China Agricultural University, Beijing 100193, China. wtaocai@163.com.ORCID 0000-0002-5639-1755
Shuli LiuDepartment of Animal Genetics and Breeding, College of Animal Science and Technology, Key Laboratoryof Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory for AnimalBreeding, China Agricultural University, Beijing 100193, China. shuliliu1991@cau.edu.cn.
Chenghao ZhouDepartment of Animal Genetics and Breeding, College of Animal Science and Technology, Key Laboratoryof Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory for AnimalBreeding, China Agricultural University, Beijing 100193, China. reddsbhj3@163.com.
Hongwei YinDepartment of Animal Genetics and Breeding, College of Animal Science and Technology, Key Laboratoryof Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory for AnimalBreeding, China Agricultural University, Beijing 100193, China. yinhongwei@cau.edu.cn.
Dongxiao SunDepartment of Animal Genetics and Breeding, College of Animal Science and Technology, Key Laboratoryof Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory for AnimalBreeding, China Agricultural University, Beijing 100193, China. sundx@cau.edu.cn.
Shengli ZhangDepartment of Animal Genetics and Breeding, College of Animal Science and Technology, Key Laboratoryof Animal Genetics and Breeding of Ministry of Agriculture, National Engineering Laboratory for AnimalBreeding, China Agricultural University, Beijing 100193, China. zhangslcau@cau.edu.cn.
China Agricultural University · CNNorthwest A&F University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heat shock 70 kDa protein 8 (HSPA8) and erb-b2 receptor tyrosine kinase 2 (ERBB2) were the promising candidates for milk protein concentration in dairy cattle revealed through previous RNA sequencing (RNA-Seq) study. The objective of this post-RNA-Seq study was to confirm genetic effects of HSPA8 and ERBB2 on milk protein concentration in a large Chinese Holstein population and to evaluate the genetic effects of both genes on other milk production traits. There were 2 singlenucleotide polymorphisms (SNPs) identified for HSPA8 and 11 SNPs for ERBB2 by sequencing 17 unrelated Chinese Holstein sires. The SNP-rs136632043 in HSPA8 had significant associations with all five milk production traits (p = 0.0086 to p < 0.0001), whereas SNP-rs132976221 was remarkably associated with three yield traits (p < 0.0001). Nine (ss1996900615, rs109017161, rs109122971, ss1996900614, rs110133654, rs109941438, rs110552983, rs133031530, and rs109763505) of 11 SNPs in ERBB2 were significantly associated with milk protein percentage (p = 0.0177 to p < 0.0001). A 12 Kb haplotype block was formed in ERBB2 and haplotype associations revealed similar effects on milk protein traits. Our findings confirmed the significant genetic effects of HSPA8 and ERBB2 on milk protein concentration and other milk production traits and SNP phenotypic variances above 1% may serve as genetic markers in dairy cattle breeding programs.

Indexed as

Polymorphism, Single NucleotideAnimalsCattleErb-b2 Receptor Tyrosine KinasesHaplotypesHSC70 Heat-Shock ProteinsMilk ProteinsQuantitative Trait, HeritableErb-b2 Receptor Tyrosine KinasesHSC70 Heat-Shock ProteinsMilk Proteinsassociation analysescandidate genesdairy cowshaplotypesmilk protein traits

Identifiers

PMID30704154
PMCPMC6409942
OpenAlexW2912774170

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.