Evidence map›Paper›PMID 30704059›Full record

ReviewToxics2019

Metabolic Syndrome and Air Pollution: A Narrative Review of Their Cardiopulmonary Effects.

Emily A Clementi, Angela Talusan, Sandhya Vaidyanathan, Arul Veerappan, Mena Mikhail, Dean Ostrofsky, George Crowley, James S Kim, Sophia Kwon, Anna Nolan

Registry-linked trialOpen access · goldAbstract readReview
In one paragraph

Review in Toxics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04815538 (The Relationship Between Workplace Environment and Metabolic Syndrome in Different Industries), which is not on this map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04815538 unknown statusnot on this mapstarted 2021, after this paper: background citation

The Relationship Between Workplace Environment and Metabolic Syndrome in Different Industries

TypeobservationalSponsorAssiut UniversityRan2021 to 2022Enrolled156ConditionsMetabolic Syndrome, Protection AgainstArmsthe subscale of Health-Promoting Lifestyle Profile II
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 57 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Emily A ClementiDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY 10016, USA. Emily.Clementi@nyumc.org.
Angela TalusanDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY 10016, USA. Angela.Talusan@nyumc.org.ORCID 0000-0002-3543-2132
Sandhya VaidyanathanDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY 10016, USA. Sandhya.Vaidyanathan@nyumc.org.
Arul VeerappanDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY 10016, USA. Arul.Veerappan@nyumc.org.
Mena MikhailDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY 10016, USA. Mena.Mikhail@nyumc.org.
Dean OstrofskyDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY 10016, USA. Dean.Ostrofsky@nyumc.org.
George CrowleyDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY 10016, USA. George.Crowley@nyumc.org.
James S KimDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY 10016, USA. Jamessungkim320@gmail.com.
Sophia KwonDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY 10016, USA. Sophia.Kwon@nyumc.org.
Anna NolanDepartment of Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY 10016, USA. anna.nolan@med.nyu.edu.
New York University · USNew York City Fire Department · US

Funding

Metabolomics of World Trade Center-Lung Injury: Biomarker Validation, Longitudinal Assessment and Dietary InterventionU01OH011300 · OH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NOLAN, ANNA · 2017 to 2025
$4.8M
RAGE Mediates LPA Induced Pulmonary InflammationR01HL119326 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI NOLAN, ANNA · 2015 to 2019
$2.1M
CDC/NIOSH U01-OH011300NHLBI NIH HHS R01HL119326
6 · The paper itself

Abstract

Particulate matter (PM) exposure and metabolic syndrome (MetSyn) are both significant global health burdens. PM exposure has been implicated in the pathogenesis of MetSyn and cardiopulmonary diseases. Individuals with pre-existing MetSyn may be more susceptible to the detrimental effects of PM exposure. Our aim was to provide a narrative review of MetSyn/PM-induced systemic inflammation in cardiopulmonary disease, with a focus on prior studies of the World Trade Center (WTC)-exposed Fire Department of New York (FDNY). We included studies (1) published within the last 16-years; (2) described the epidemiology of MetSyn, obstructive airway disease (OAD), and vascular disease in PM-exposed individuals; (3) detailed the known mechanisms of PM-induced inflammation, MetSyn and cardiopulmonary disease; and (4) focused on the effects of PM exposure in WTC-exposed FDNY firefighters. Several investigations support that inhalation of PM elicits pulmonary and systemic inflammation resulting in MetSyn and cardiopulmonary disease. Furthermore, individuals with these preexisting conditions are more sensitive to PM exposure-related inflammation, which can exacerbate their conditions and increase their risk for hospitalization and chronic disease. Mechanistic research is required to elucidate biologically plausible therapeutic targets of MetSyn- and PM-induced cardiopulmonary disease.

Indexed as

blood pressurecardiovascular diseasechronic obstructive pulmonary diseasemetabolic syndromeparticulate mattersystemic inflammationWorld Trade Center

Identifiers

PMID30704059
PMCPMC6468691
OpenAlexW2911953184

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.