Evidence map›Paper›PMID 30704053›Full record

ReviewMolecules (Basel, Switzerland)2019

Shining a Spotlight on DNA: Single-Molecule Methods to Visualise DNA.

Gurleen Kaur, Jacob S Lewis, Antoine M van Oijen

Abstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Hidden Fungal DNA Structures May Shape Sequencing Outcomes.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Real-Time Feedback-Driven Single-Particle Tracking: A Survey and Perspective.Small (Weinheim an der Bergstrasse, Germany) · 2022
    Review
  11. Review
  12. Review
  13. Oriented Soft DNA Curtains for Single-Molecule Imaging.Langmuir : the ACS journal of surfaces and colloids · 2021
    Article
  14. DNA Manipulation and Single-Molecule Imaging.Molecules (Basel, Switzerland) · 2021
    Review
  15. Review
  16. Article
  17. Illuminating amyloid fibrils: Fluorescence-based single-molecule approaches.Computational and structural biotechnology journal · 2021
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gurleen KaurSchool of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, Wollongong 2522, Australia. gk980@uowmail.edu.au.
Jacob S LewisSchool of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, Wollongong 2522, Australia. jacobl@uow.edu.au.ORCID 0000-0002-9945-6133
Antoine M van OijenSchool of Chemistry and Molecular Bioscience and Molecular Horizons, University of Wollongong, Wollongong 2522, Australia. vanoijen@uow.edu.au.

Funding

Australian Research Council DP180100858Australian Research Council FL140100027
6 · The paper itself

Abstract

The ability to watch single molecules of DNA has revolutionised how we study biological transactions concerning nucleic acids. Many strategies have been developed to manipulate DNA molecules to investigate mechanical properties, dynamics and protein⁻DNA interactions. Imaging methods using small molecules and protein-based probes to visualise DNA have propelled our understanding of complex biochemical reactions involving DNA. This review focuses on summarising some of the methodological developments made to visualise individual DNA molecules and discusses how these probes have been used in single-molecule biophysical assays.

Indexed as

Single Molecule ImagingBiophysical PhenomenaDNADNA-Binding ProteinsDNA ReplicationDNA, Single-StrandedFluorescent DyesMicroscopy, FluorescencePolymersSequence Analysis, DNADNADNA-Binding ProteinsDNA, Single-StrandedFluorescent DyesPolymersDNADNA complexesfluorescence microscopyprotein complexessingle molecules

Identifiers

PMID30704053
PMCPMC6384704

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.