ArticleiScience2019
Asymmetrical 3D Nanoceria Channel for Severe Neurological Defect Regeneration.
Article in iScience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Advances in biomaterial-based tissue engineering for peripheral nerve injury repair.Bioactive materials · 2025Review
- Peripheral Nerve Injury Induced by Japanese Encephalitis Virus in C57BL/6 Mouse.Journal of virology · 2023Article
- Spore Oil-Functionalized Selenium Nanoparticles Protect Pancreatic Beta Cells from Palmitic Acid-Induced Apoptosis via Inhibition of Oxidative Stress-Mediated Apoptotic Pathways.Antioxidants (Basel, Switzerland) · 2023Article
- Energy-Supporting Enzyme-Mimic Nanoscaffold Facilitates Tendon Regeneration Based on a Mitochondrial Protection and Microenvironment Remodeling Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- 3D Printed Personalized Nerve Guide Conduits for Precision Repair of Peripheral Nerve Defects.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Review
- Fabrication Techniques of Nerve Guidance Conduits for Nerve Regeneration.Yonsei medical journal · 2022Review
- Graphdiyne-Related Materials in Biomedical Applications and Their Potential in Peripheral Nerve Tissue Engineering.Cyborg and bionic systems (Washington, D.C.) · 2022Review
- Programming of Regulatory T Cells In Situ for Nerve Regeneration and Long-Term Patency of Vascular Grafts.Research (Washington, D.C.) · 2022Article
- Biomechanical microenvironment in peripheral nerve regeneration: from pathophysiological understanding to tissue engineering development.Theranostics · 2022Review
- A multifunctional ATP-generating system by reduced graphene oxide-based scaffold repairs neuronal injury by improving mitochondrial function and restoring bioelectricity conduction.Materials today. Bio · 2022Article
- Antioxidant for Neurological Diseases and Neurotrauma and Bioengineering Approaches.Antioxidants (Basel, Switzerland) · 2021Review
- The balanced microenvironment regulated by the degradants of appropriate PLGA scaffolds and chitosan conduit promotes peripheral nerve regeneration.Materials today. Bio · 2021Article
- The influence of reduced graphene oxide on stem cells: a perspective in peripheral nerve regeneration.Regenerative biomaterials · 2021Review
- Biological and biocompatible characteristics of fullerenols nanomaterials for tissue engineering.Histology and histopathology · 2021Review
- Preclinical assessment on neuronal regeneration in the injury-related microenvironment of graphene-based scaffolds.NPJ Regenerative medicine · 2021Article
- Tacrolimus-Induced Neurotrophic Differentiation of Adipose-Derived Stem Cells as Novel Therapeutic Method for Peripheral Nerve Injury.Frontiers in cellular neuroscience · 2021Article
- Two-Dimensional Nanomaterials for Peripheral Nerve Engineering: Recent Advances and Potential Mechanisms.Frontiers in bioengineering and biotechnology · 2021Review
- Cerium Oxide Nanoparticles (Nanoceria): Hopes in Soft Tissue Engineering.Molecules (Basel, Switzerland) · 2020Review
- Cerium Oxide Nanoparticles: Recent Advances in Tissue Engineering.Materials (Basel, Switzerland) · 2020Review
- Additive Manufacturing of Nerve Guidance Conduits for Regeneration of Injured Peripheral Nerves.Frontiers in bioengineering and biotechnology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammation and oxidative stress are major problems in peripheral nerve injury. Nanoceria can manipulate antioxidant factor expression, stimulate angiogenesis, and assist in axonal regeneration. We fabricate collagen/nanoceria/polycaprolactone (COL/NC/PCL) conduit by asymmetrical three-dimensional manufacture and find that this scaffold successfully improves Schwann cell proliferation, adhesion, and neural expression. In a 15-mm rat sciatic nerve defect model, we further confirm that the COL/NC/PCL conduit markedly alleviates inflammation and oxidative stress, improves microvessel growth, and contributes to functional, electrophysiological, and morphological nerve restoration in the long term. Our findings provide compelling evidence for future research in antioxidant nerve conduit for severe neurological defects.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.