Evidence map›Paper›PMID 30703394›Full record

ArticleBehavioural brain research2019

Associations between brain structure and perceived intensity of sweet and bitter tastes.

Liang-Dar Hwang, Lachlan T Strike, Baptiste Couvy-Duchesne, Greig I de Zubicaray, Katie McMahon, Paul A S Breslin, Danielle R Reed, Nicholas G Martin, Margaret J Wright

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Behavioural brain research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
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  6. Artificial selection on brain size leads to matching changes in overall number of neurons.Evolution; international journal of organic evolution · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Liang-Dar HwangQueensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia; University of Queensland Diamantina Institute, University of Queensland, Translational Research Institute, Brisbane, Queensland, Australia; Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia; QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Electronic address: d.hwang@uq.edu.au.
Lachlan T StrikeQueensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
Baptiste Couvy-DuchesneInstitute for Bioscience, University of Queensland, Brisbane, Queensland, Australia.
Greig I de ZubicarayFaculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
Katie McMahonFaculty of Health, and Institute of Health and Biomedical Innovation, Queensland University of Technology, Kelvin Grove, Queensland, Australia; School of Clinical Science, Queensland University of Technology, Kelvin Grove, Queensland, Australia.
Paul A S BreslinMonell Chemical Senses Center, Philadelphia, PA, USA; Dept. of Nutritional Sciences, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ, USA.
Danielle R ReedMonell Chemical Senses Center, Philadelphia, PA, USA.
Nicholas G MartinQIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Margaret J WrightQueensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia; Centre for Advanced Imaging, University of Queensland, Brisbane, Queensland, Australia.
The University of Queensland · AUQueensland University of Technology · AUMonell Chemical Senses Center · USQIMR Berghofer Medical Research Institute · AURutgers, The State University of New Jersey · USTranslational Research Institute · AU

Funding

Human Umami Taste: Genetics of Psychophysical TraitsR01DC002995 · NIDCD · RUTGERS, THE STATE UNIV OF N.J. · PI BRESLIN, PAUL A. S · 2002 to 2012
$4.2M
Genetic influences on the brain: A twin imaging studyR01HD050735 · NICHD · QUEENSLAND INSTITUTE OF MEDICAL RESEARCH · PI WRIGHT, MARGARET JANE · 2007 to 2011
$2.6M
TASTE MATCHING--GUSTATORY EQUIVALENCE CLASSESR29DC002995 · NIDCD · MONELL CHEMICAL SENSES CENTER · PI BRESLIN, PAUL A.S. · 1997 to 2001
$200k
NICHD NIH HHS R01 HD050735NIDCD NIH HHS R01 DC002995NIDCD NIH HHS R29 DC002995
6 · The paper itself

Abstract

Functional neuroimaging studies have identified brain regions associated with human taste perception, but only a few have investigated the associations with brain structure. Here, in this exploratory study, we examined the association between the volumes of 82 regions of interest (ROI) and the perceived intensities of sweet (a weighted mean rating of glucose, fructose, aspartame, neohesperidin dihydrochalcone) and bitter (propylthiouracil, quinine, caffeine) substances in a large Australian healthy cohort from the Queensland Twin IMaging (QTIM, n = 559) study and the perceived intensity of quinine in a large U.S. healthy cohort from the Human Connectome Project (HCP, n = 1101). In QTIM, the volumes of 3 cortical (right cuneus gyrus, left transverse temporal gyrus, right inferior temporal gyrus) and one subcortical structure (both left and right caudate) were associated with more than one taste stimulus (P < 0.05) and tended to be associated with both sweet and bitter tastes in the same direction, suggesting these ROIs were more broadly tuned for taste sensation. A further 11 ROIs were associated with a specific taste (sweetness: 4; propylthiouracil: 3; caffeine: 2; quinine: 2). In HCP, volumes of 5 ROIs were associated with quinine bitterness. The quinine-left entorhinal cortex association was found in both QTIM (r = -0.12, P = 3.7 × 10

Indexed as

AdultAustraliaAversive AgentsBrainCaffeineConnectomeFemaleHumansMalePropylthiouracilQuinineSucroseSweetening AgentsTasteTaste PerceptionAversive AgentsCaffeinePropylthiouracilQuinineSucroseSweetening AgentsBitterBrain structureGustatory cortexSweetTaste

Identifiers

PMID30703394
PMCPMC6470356
OpenAlexW2911895546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.