SynthesisPrenatal diagnosis2019
Maternal complications following open and fetoscopic fetal surgery: A systematic review and meta-analysis.
Synthesis in Prenatal diagnosis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06290232 (Fetoscopic Laser Photocoagulation in Management of Vasa Previa - FLUMEN Study), which is not on this map. Cited by 40 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fetoscopic Laser Photocoagulation in Management of Vasa Previa - FLUMEN Study
Who cites it
40 citing papers in PubMed, 4 syntheses or guidelines pooled it, 145 citations in OpenAlex.
- Impact of cannula diameter on pregnancy outcomes after minimally invasive fetal laser surgery in the treatment of twin-to-twin transfusion syndrome: A systematic review and meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2024Pooled it
- What brain abnormalities can magnetic resonance imaging detect in foetal and early neonatal spina bifida: a systematic review.Neuroradiology · 2022Pooled it
- Fetal Diagnosis and Therapy during the COVID-19 Pandemic: Guidance on Behalf of the International Fetal Medicine and Surgery Society.Fetal diagnosis and therapy · 2020Guideline
- Maternal complications following open and fetoscopic fetal surgery: A systematic review and meta-analysis.Prenatal diagnosis · 2019Pooled it
- Randomized Trial of Fetal Surgery for Severe Left Diaphragmatic Hernia.The New England journal of medicine · 2021Trial
- International Expert Consensus on the Diagnosis and Clinical Management of Primary Fetal Pleural Effusion.Prenatal diagnosis · 2026Article
- Perceived satisfaction in fetal therapy: proposal and pilot of a novel assessment tool (FETAL Surgery Global Satisfaction).BMC pregnancy and childbirth · 2026Article
- Persistent compression of uterine insertion on maternal blood dynamic change in fetoscopic laser photocoagulation surgery: a novel method.BMC pregnancy and childbirth · 2026Article
- Fetoscopic repair of myeloschisis: optimizing the three-layer closure.Neurosurgical focus: Video · 2026Article
- Article
- Maternal outcomes following prenatal spina bifida repair: A systematic review and meta-analysis.Pregnancy (Hoboken, N.J.) · 2026Review
- Patient-Reported Outcome Measures in Fetal Medicine: A Pilot Feasibility Study.Prenatal diagnosis · 2025Article
- The effect of uterine entry technique on chorioamniotic membrane separation in fetoscopic laser photocoagulation for twin-to-twin transfusion syndrome: protocol for a randomized controlled trial.BMC pregnancy and childbirth · 2025Article
- Advances in Fetal Surgery: A Narrative Review of Therapeutic Interventions and Future Directions.Medicina (Kaunas, Lithuania) · 2025Review
- Cesarean section with operation on placental support as an adapted EXIT procedure for fetal thyroid goiter: A case report and literature review.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2025Review
- Evaluation of Intrinsic Fetal Airway Obstruction (CHAOS): Correlations Between Ultrasound, Fetoscopic, and Pathological Findings.Prenatal diagnosis · 2025Article
- Fetoscopic Endoluminal Tracheal Occlusion-Synergic Therapies in the Prenatal Treatment of Congenital Diaphragmatic Hernia.International journal of molecular sciences · 2025Review
- Ethical issues in fetal therapies of life-threatening malformations.European journal of pediatrics · 2024Review
- Major surgical conditions of childhood and their lifelong implications: comprehensive review.BJS open · 2024Review
- Atypical twin-to-twin transfusion syndrome case managed in a single centre in Indonesia with fetoscopic laser photocoagulation and amniopatch: 'Case Report'.Annals of medicine and surgery (2012) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 4 countries.
Funding
Abstract
objectiveTo establish maternal complication rates for fetoscopic or open fetal surgery.
methodsWe conducted a systematic literature review for studies of fetoscopic or open fetal surgery performed since 1990, recording maternal complications during fetal surgery, the remainder of pregnancy, delivery, and after the index pregnancy.
resultsOne hundred sixty-six studies were included, reporting outcomes for open fetal (n = 1193 patients) and fetoscopic surgery (n = 9403 patients). No maternal deaths were reported. The risk of any maternal complication in the index pregnancy was 20.9% (95%CI, 15.22-27.13) for open fetal and 6.2% (95%CI, 4.93-7.49) for fetoscopic surgery. For severe maternal complications (grades III to V Clavien-Dindo classification of surgical complications), the risk was 4.5% (95% CI 3.24-5.98) for open fetal and 1.7% (95% CI, 1.19-2.20) for fetoscopic surgery. In subsequent pregnancies, open fetal surgery increased the risk of preterm birth but not uterine dehiscence or rupture. Nearly one quarter of reviewed studies (n = 175, 23.3%) was excluded for failing to report the presence or absence of maternal complications.
conclusionsMaternal complications occur in 6.2% fetoscopic and 20.9% open fetal surgeries, with serious maternal complications in 1.7% fetoscopic and 4.5% open procedures. Reporting of maternal complications is variable. To properly quantify maternal risks, outcomes should be reported consistently across all fetal surgery studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.