ArticlePloS one2019
Determinants of corrosion resistance of Ti-6Al-4V alloy dental implants in an In Vitro model of peri-implant inflammation.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 71 citations in OpenAlex.
- The immune-microbe-metal triad: a vicious cycle driving biomaterial corrosion in the oral inflammatory microenvironment.Bioactive materials · 2027Review
- Titanium Degradation Products from Dental Implants: Mechanisms of Release, Biodistribution, and Analytical Detection in Biological Matrices.International journal of molecular sciences · 2026Review
- Electrochemical Interactions of Titanium and Cobalt-Chromium-Molybdenum Alloy in Different Solutions.Materials (Basel, Switzerland) · 2026Article
- Electrochemical Behavior and Cytocompatibility of Titanium Dental Implants Under Different Chemical Treatments.Biomedicines · 2025Article
- Advances in Dealloying of Ti and Ti-Based Alloys for Biomedical Applications.Materials (Basel, Switzerland) · 2025Review
- Microbial Dysbiosis, Titanium Release, and Peri-implantitis.Journal of dental research · 2025Review
- Effect of Tribocorrosion on Mechanical Behavior of Titanium Dental Implants: An In Vitro Study.Materials (Basel, Switzerland) · 2025Article
- Dynamic assessment of titanium surface oxides following mechanical damage reveals only partial passivation under inflammatory conditions.Npj Materials degradation · 2024Article
- Atomic layer deposited TiOFrontiers in bioengineering and biotechnology · 2024Article
- Biomedical Applications of Titanium Alloys: A Comprehensive Review.Materials (Basel, Switzerland) · 2023Review
- Corrosion Resistance of Titanium Dental Implant Abutments: Comparative Analysis and Surface Characterization.Materials (Basel, Switzerland) · 2023Article
- Surface structure characteristics of dental implants and their potential changes following installation: a literature review.Journal of the Korean Association of Oral and Maxillofacial Surgeons · 2023Article
- Nanoscale Chemical Surface Analyses of Recycled Powder for Direct Metal Powder Bed Fusion Ti-6Al-4V Root Analog Dental Implant: An X-ray Photoelectron Spectroscopy Study.Bioengineering (Basel, Switzerland) · 2023Article
- Electrochemical and biological characterization of Ti-Nb-Zr-Si alloy for orthopedic applications.Scientific reports · 2023Article
- Immunomodulatory biomaterials for implant-associated infections: from conventional to advanced therapeutic strategies.Biomaterials research · 2022Review
- Microstructural Modification of TiAl6V4 Alloy to Avoid Detrimental Effects Due to Selective In Vivo Crevice Corrosion.Materials (Basel, Switzerland) · 2022Article
- Electrical Potentiometry with Intraoral Applications.Materials (Basel, Switzerland) · 2022Article
- The Electrochemical Behavior of Ti in Human Synovial Fluids.Materials (Basel, Switzerland) · 2022Article
- Osteoimmune regulation underlies oral implant osseointegration and its perturbation.Frontiers in immunology · 2022Review
- Advanced Surface Modification for 3D-Printed Titanium Alloy Implant Interface Functionalization.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTitanium (Ti) and its alloys possess high biocompatibility and corrosion resistance due to Ti ability to form a passive oxide film, i.e. TiO2, immediately after contact with oxygen. This passive layer is considered stable during function in the oral cavity, however, emerging information associate inflammatory peri-implantitis to vast increases in Ti corrosion products around diseased implants as compared to healthy ones. Thus, it is imperative to identify which factors in the peri-implant micro-environment may reduce Ti corrosion resistance.
methodsThe aim of this work is to simulate peri-implant inflammatory conditions in vitro to determine which factors affect corrosion susceptibility of Ti-6Al-4V dental implants. The effects of hydrogen peroxide (surrogate for reactive oxygen species, ROS, found during inflammation), albumin (a protein typical of physiological fluids), deaeration (to simulate reduced pO2 conditions during inflammation), in an acidic environment (pH 3), which is typical of inflammation condition, were investigated. Corrosion resistance of Ti-6Al-4V clinically-relevant acid etched surfaces was investigated by electrochemical techniques: Open Circuit Potential; Electrochemical Impedance Spectroscopy; and Anodic Polarization.
resultsElectrochemical tests confirmed that most aggressive conditions to the Ti-6Al-4V alloy were those typical of occluded cells, i.e. oxidizing conditions (H2O2), in the presence of protein and deaeration of the physiological medium.
conclusionsOur results provide evidence that titanium's corrosion resistance can be reduced by intense inflammatory conditions. This observation indicates that the micro-environment to which the implant is exposed during peri-implant inflammation is highly aggressive and may lead to TiO2 passive layer attack. Further investigation of the effect of these aggressive conditions on titanium dissolution is warranted.
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