ArticlePLoS computational biology2019
Dynamical differential expression (DyDE) reveals the period control mechanisms of the Arabidopsis circadian oscillator.
Article in PLoS computational biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Magnesium: An overlooked signalling ion in plant physiology and circadian regulation.Quantitative plant biology · 2026Review
- Unlocking gene regulatory networks for crop resilience and sustainable agriculture.Nature biotechnology · 2025Review
- Inferring upstream regulatory genes of FOXP3 in human regulatory T cells from time-series transcriptomic data.NPJ systems biology and applications · 2024Article
- Circadian entrainment in Arabidopsis.Plant physiology · 2022Article
- Magnesium maintains the length of the circadian period in Arabidopsis.Plant physiology · 2021Article
- Gene regulatory network inference from sparsely sampled noisy data.Nature communications · 2020Article
- The Rhythm of the Light: How Light and the Clock Drive Cycling of Transcript Levels in Barley.Plant physiology · 2020Article
- Differential Effects of Day/Night Cues and the Circadian Clock on the Barley Transcriptome.Plant physiology · 2020Article
- Light Perception: A Matter of Time.Molecular plant · 2020Review
- Recent advances in understanding regulation of the Arabidopsis circadian clock by local cellular environment.F1000Research · 2020Review
- Continuous dynamic adjustment of the plant circadian oscillator.Nature communications · 2019Review
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 2 countries.
Funding
Abstract
The circadian oscillator, an internal time-keeping device found in most organisms, enables timely regulation of daily biological activities by maintaining synchrony with the external environment. The mechanistic basis underlying the adjustment of circadian rhythms to changing external conditions, however, has yet to be clearly elucidated. We explored the mechanism of action of nicotinamide in Arabidopsis thaliana, a metabolite that lengthens the period of circadian rhythms, to understand the regulation of circadian period. To identify the key mechanisms involved in the circadian response to nicotinamide, we developed a systematic and practical modeling framework based on the identification and comparison of gene regulatory dynamics. Our mathematical predictions, confirmed by experimentation, identified key transcriptional regulatory mechanisms of circadian period and uncovered the role of blue light in the response of the circadian oscillator to nicotinamide. We suggest that our methodology could be adapted to predict mechanisms of drug action in complex biological systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.