ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2019
Differential biomechanical properties of mouse distal colon and rectum innervated by the splanchnic and pelvic afferents.
Article in American journal of physiology. Gastrointestinal and liver physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Mechanical experimentation of the gastrointestinal tract: a systematic review.Biomechanics and modeling in mechanobiology · 2024Pooled it
- Colorectum and embedded networks of nerve fibers present auxetic responses during uniaxial circumferential extension.Acta biomaterialia · 2026Article
- Biochemical and Physiological Effects of Galanin in Health and Disease.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Review
- Metformin and butyrate attenuate chronic radiation proctitis by alleviating inflammation and macrophage senescence.Frontiers in immunology · 2026Article
- Understanding mechanotransduction in the distal colon and rectum via multiscale and multimodal computational modeling.Journal of the mechanical behavior of biomedical materials · 2024Article
- Identification of Arginine-Vasopressin Receptor 1a (Avpr1a/Avpr1a) as a Novel Candidate Gene for Chronic Visceral Pain Sheds Light on the Potential Role of Enteric Neurons in the Development of Visceral Hypersensitivity.The journal of pain · 2024Article
- Calcium image analysis in the moving gut.Neurogastroenterology and motility · 2023Article
- Mechanobiological considerations in colorectal stapling: Implications for technology development.Surgery open science · 2023Review
- Layer-Specific Damage Modeling of Porcine Large Intestine under Biaxial Tension.Bioengineering (Basel, Switzerland) · 2022Article
- Fabricating a Low-Cost, Microscopy-Compatible Mechanical Testing Device.Experimental techniques · 2022Article
- Predicting the micromechanics of embedded nerve fibers using a novel three-layered model of mouse distal colon and rectum.Journal of the mechanical behavior of biomedical materials · 2022Article
- Toward Elucidating the Physiological Impacts of Residual Stresses in the Colorectum.Journal of biomechanical engineering · 2022Article
- Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise.International journal of environmental research and public health · 2021Review
- Optical clearing reveals TNBS-induced morphological changes of VGLUT2-positive nerve fibers in mouse colorectum.American journal of physiology. Gastrointestinal and liver physiology · 2021Article
- The heterogeneous morphology of networked collagen in distal colon and rectum of mice quantified via nonlinear microscopy.Journal of the mechanical behavior of biomedical materials · 2021Article
- Computational Modeling of Mouse Colorectum Capturing Longitudinal and Through-thickness Biomechanical Heterogeneity.Journal of the mechanical behavior of biomedical materials · 2021Article
- The Macro- and Micro-Mechanics of the Colon and Rectum II: Theoretical and Computational Methods.Bioengineering (Basel, Switzerland) · 2020Review
- The Macro- and Micro-Mechanics of the Colon and Rectum I: Experimental Evidence.Bioengineering (Basel, Switzerland) · 2020Review
- Visceral pain from colon and rectum: the mechanotransduction and biomechanics.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli.Physiological reports · 2020Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Visceral pain is one of the principal complaints of patients with irritable bowel syndrome, and this pain is reliably evoked by mechanical distension and stretch of distal colon and rectum (colorectum). This study focuses on the biomechanics of the colorectum that could play critical roles in mechanical neural encoding. We harvested the distal 30 mm of the colorectum from mice, divided evenly into three 10-mm-long segments (colonic, intermediate and rectal), and conducted biaxial mechanical stretch tests and opening-angle measurements for each tissue segment. In addition, we determined the collagen fiber orientations and contents across the thickness of the colorectal wall by nonlinear imaging via second harmonic generation (SHG). Our results reveal a progressive increase in tissue compliance and prestress from colonic to rectal segments, which supports prior electrophysiological findings of distinct mechanical neural encodings by afferents in the lumbar splanchnic nerves (LSN) and pelvic nerves (PN) that dominate colonic and rectal innervations, respectively. The colorectum is significantly more viscoelastic in the circumferential direction than in the axial direction. In addition, our SHG results reveal a rich collagen network in the submucosa and orients approximately ±30° to the axial direction, consistent with the biaxial test results presenting almost twice the stiffness in axial direction versus the circumferential direction. Results from current biomechanical study strongly indicate the prominent roles of local tissue biomechanics in determining the differential mechanical neural encoding functions in different regions of the colorectum. NEW & NOTEWORTHY Mechanical distension and stretch-not heat, cutting, or pinching-reliably evoke pain from distal colon and rectum. We report different local mechanics along the longitudinal length of the colorectum, which is consistent with the existing literature on distinct mechanotransduction of afferents innervating proximal and distal regions of the colorectum. This study draws attention to local mechanics as a potential determinant factor for mechanical neural encoding of the colorectum, which is crucial in visceral nociception.
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Registered trials
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