Evidence map›Paper›PMID 30702429›Full record

ArticleeLife2019

Anillin regulates epithelial cell mechanics by structuring the medial-apical actomyosin network.

Torey R Arnold, Joseph H Shawky, Rachel E Stephenson, Kayla M Dinshaw, Tomohito Higashi, Farah Huq, Lance A Davidson, Ann L Miller

Open access · goldAbstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 56 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Shape, Strain, and Stability: Epithelia Under High Strain.bioRxiv : the preprint server for biology · 2025
    Article
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  15. Patterning of the cell cortex by Rho GTPases.Nature reviews. Molecular cell biology · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Torey R ArnoldDepartment of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.ORCID 0000-0002-1663-1953
Joseph H ShawkyDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, United States.
Rachel E StephensonDepartment of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.
Kayla M DinshawDepartment of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.
Tomohito HigashiDepartment of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.ORCID 0000-0001-5616-1477
Farah HuqDepartment of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.
Lance A DavidsonDepartment of Developmental Biology, University of Pittsburgh, Pittsburgh, United States.ORCID 0000-0002-2956-0437
Ann L MillerDepartment of Molecular Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States.ORCID 0000-0002-7293-764X
University of Michigan · USUniversity of Pittsburgh · US

Funding

Training in Biomechanics in Regenerative MedicineT32EB003392 · NIBIB · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WOO, SAVIO L-Y. · 2005 to 2020
$4.0M
The Biomechanics of morphogenesis in the frogR01HD044750 · NICHD · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI DAVIDSON, LANCE A. · 2005 to 2020
$3.8M
Regulation of localized RhoA activity in dividing epithelial cellsR01GM112794 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MILLER, ANN LOUISE · 2015 to 2023
$3.0M
Mechanical Control of Mesenchymal-to-Epithelial TransitionR56HL134195 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DAVIDSON, LANCE A. · 2016 to 2016
$550k
Arnold and Mabel Beckman Foundation Beckman Scholars FellowshipEunice Kennedy Shriver National Institute of Child Health and Human Development R01 HD04475Japan Society for the Promotion of Science Postdoctoral FellowshipNational Science Foundation Graduate Research FellowshipNHLBI NIH HHS R56 HL134195NIBIB NIH HHS T32 EB003392NICHD NIH HHS R01 HD044750NIGMS NIH HHS R01 GM112794NIH HHS Biomechanics in Regenerative Medicine Training GrantRackham Graduate School Rackham Merit Fellowship
6 · The paper itself

Abstract

Cellular forces sculpt organisms during development, while misregulation of cellular mechanics can promote disease. Here, we investigate how the actomyosin scaffold protein anillin contributes to epithelial mechanics in

Indexed as

ActinsActomyosinAdenosine TriphosphateAnimalsBiomechanical PhenomenaCell PolarityContractile ProteinsEmbryo, NonmammalianEpithelial CellsMyosin Type IIProtein BindingProtein DomainsProtein StabilityVinculinXenopus laevisActinsActomyosinAdenosine TriphosphateanillinContractile ProteinsMyosin Type IIVinculinactinanillincell biologycontractilitydevelopmental biologyepitheliumlaser ablationtissue mechanicsxenopus

Identifiers

PMID30702429
PMCPMC6424563
OpenAlexW2914539771

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.