ArticleTransfusion2019
Probable transmission of hepatitis E virus (HEV) via transfusion in the United States.
Article in Transfusion, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Epidemiology of HEV Infection in Blood Donors in Southern Switzerland.Microorganisms · 2023Article
- Chronic hepatitis E in an elderly immunocompetent patient who achieved a sustained virologic response with ribavirin treatment.Clinical journal of gastroenterology · 2023Article
- Higher Risk of HEV Transmission and Exposure among Blood Donors in Europe and Asia in Comparison to North America: A Meta-Analysis.Pathogens (Basel, Switzerland) · 2023Review
- Transmission of Hepatitis E Virus.Advances in experimental medicine and biology · 2023Article
- Hepatitis E in immunocompromised individuals.World journal of hepatology · 2022Review
- Transfusion-transmitted hepatitis E: What we know so far?World journal of gastroenterology · 2022Review
- Hepatitis E Infection in a Longitudinal Cohort of Hepatitis C Virus and HCV/HIV Coinfected Persons.AIDS research and human retroviruses · 2021Article
- Advances in Hepatitis E Virus Biology and Pathogenesis.Viruses · 2021Review
- Deep sequencing applied to the analysis of viromes in patients with beta-thalassemia.Revista do Instituto de Medicina Tropical de Sao Paulo · 2021Article
- Antibody-enhanced hepatitis E virus nanofiltration during the manufacture of human immunoglobulin.Transfusion · 2020Article
- Hepatitis E Virus in Pigs from Slaughterhouses, United States, 2017-2019.Emerging infectious diseases · 2020Article
- Systematic Comparison of the Effect of Four Clinical-Grade Platelet Rich Hemoderivatives on Osteoblast Behaviour.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundHepatitis E virus (HEV) can inapparently infect blood donors. To assess transfusion transmission of HEV in the United States, which has not been documented, a donor-recipient repository was evaluated. STUDY DESIGN AND
methodsTo identify donations that contained HEV RNA and were linked to patient-recipients with antibody evidence of HEV exposure, we assayed samples from the Retrovirus Epidemiology Donor Study (REDS) Allogeneic Donor and Recipient repository that represents 13,201 linked donations and 3384 transfused patients. Posttransfusion samples, determined to contain IgG anti-HEV by enzyme-linked immunosorbent assay, were reassayed along with corresponding pretransfusion samples for seroconversion (incident exposure) or at least fourfold IgG anti-HEV increase (reexposure). HEV-exposed patients were linked to donations in which HEV RNA was then detected by reverse-transcription quantitative polymerase chain reaction, confirmed by transcription-mediated amplification, and phylogenetically analyzed as subgenomic cDNA sequences.
resultsAmong all patients, 19 of 1036 (1.8%) who had IgG anti-HEV before transfusion were reexposed; 40 of 2348 (1.7%) without pretransfusion IgG anti-HEV seroconverted. These 59 patients were linked to 257 donations, 1 of which was positive by reverse-transcription quantitative polymerase chain reaction and transcription-mediated amplification. Plasma from this donation contained 5.5 log IU/mL of HEV RNA that grouped with HEV genotype 3, clade 3abchij. The patient-recipient of RBCs from this donation had a greater than eightfold IgG increase; however, clinical data are unavailable.
conclusionsThis is the first report of probable HEV transmission via transfusion in the United States, although it has been frequently observed in Europe and Japan. Additional data on the magnitude of the risk in the United States are needed.
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