Trial reportJournal of investigative and clinical dentistry2019
Impact of a non-fluoridated microcrystalline hydroxyapatite dentifrice on enamel caries progression in highly caries-susceptible orthodontic patients: A randomized, controlled 6-month trial.
Trial report in Journal of investigative and clinical dentistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 44 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Enamel Caries in Orthodontic Patients
Clinical and Laboratory Effectiveness of Different Toothpastes in Treating White Spot Lesions
Who cites it
44 citing papers in PubMed, 4 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Efficacy of various interventions for the management of white spot lesions associated with fixed orthodontic treatment: a systematic review and network meta-analysis of randomized controlled trials.BMC oral health · 2026Pooled it
- Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis.Clinical oral investigations · 2022Pooled it
- Biomimetic hydroxyapatite and caries prevention: a systematic review and meta-analysis.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2021Pooled it
- Effectiveness of remineralizing agents in the prevention and reversal of orthodontically induced white spot lesions: a systematic review and network meta-analysis.Clinical oral investigations · 2020Pooled it
- Hydroxyapatite-Fluoride Toothpastes on Caries Activity: A Triple-Blind Randomized Clinical Trial.International dental journal · 2025Trial
- Caries-preventing effect of a hydroxyapatite-toothpaste in adults: a 18-month double-blinded randomized clinical trial.Frontiers in public health · 2023Trial
- Impact of a toothpaste with microcrystalline hydroxyapatite on the occurrence of early childhood caries: a 1-year randomized clinical trial.Scientific reports · 2021Trial
- Impact of a non-fluoridated microcrystalline hydroxyapatite dentifrice on enamel caries progression in highly caries-susceptible orthodontic patients: A randomized, controlled 6-month trial.Journal of investigative and clinical dentistry · 2019Trial
- Navigating fluoride hesitancy: mapping the evidence base for fluoride-free toothpaste alternatives.European journal of pediatrics · 2026Review
- Efficacy of calcium hypophosphite toothpaste in remineralizing initial caries in vitro.BMC oral health · 2026Article
- In vitro study on the neutralization potential of particulate hydroxyapatite in erosive acids.BDJ open · 2026Article
- Comparison of the Caries Remineralizing Effects of Dentifrices Based on Natural Hydroxyapatite, Synthetic Hydroxyapatite, and Fluoride: A pH Cycling Study.Biomimetics (Basel, Switzerland) · 2026Article
- Fluoride-Free Toothpastes for Caries Prevention: A Systematic Review of Clinical Evidence on Active Ingredients.Clinical, cosmetic and investigational dentistry · 2026Review
- Nano-Hydroxyapatite-Based Mouthwash for Comprehensive Oral Care: Activity Against Bacterial and Fungal Pathogens with Antioxidant and Anti-Inflammatory Action.Materials (Basel, Switzerland) · 2025Article
- Comparison of the remineralization effectiveness of three remineralizing agents on artificial enamel lesions: an in vitro study.BDJ open · 2025Article
- Case Report on Caries Assessment Using Intraoral Scanner Compared with Bitewing Radiographs.European journal of dentistry · 2024Article
- Caries Etiology and Preventive Measures.European journal of dentistry · 2024Article
- Formulation and Evaluation of Characteristics, Remineralization Potential, and Antimicrobial Properties of Toothpaste Containing Nanohydroxyapatite and Nanosilver Particles: AnInternational journal of clinical pediatric dentistry · 2024Article
- Review
- Doses of fluoride toothpaste for children up to 24 months.BDJ open · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
Abstract
aimThe aim of the present randomized, controlled trial was to compare the impact of the regular use of a fluoride-free microcrystalline hydroxyapatite (HAP) dentifrice and a 1400 ppm fluoride control dentifrice on caries progression in 150 highly caries-active orthodontic patients.
methodsThe primary outcome was the occurrence of lesions with International Caries Detection and Assessment System (ICDAS) ≥code 1 on the vestibular surfaces of teeth 15-25 within 168 days after fixation of orthodontic brackets. Secondary outcomes were lesion development ICDAS ≥code 2, the plaque index, and the gingival index.
resultsIn total, 147 patients were included in the intent-to-treat (ITT) analysis; 133 finished the study per protocol (PP). An increase in enamel caries ICDAS ≥code 1 was observed in 56.8% (ITT) and 54.7% (PP) of the HAP group participants compared with 60.9% (ITT) and 61.6% (PP) of the fluoride control group. Non-inferiority testing (ITT and PP) demonstrated the absence of a significant difference between the groups. No significant differences in secondary outcomes were observed between the groups.
conclusionIn highly caries-active patients, the impact of the regular use of a microcrystalline HAP dentifrice on caries progression is not significantly different from the use of a 1400 ppm fluoride toothpaste (ClinicalTrials.gov: NCT02705456).
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.