ArticleCancer medicine2019
Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes.
Article in Cancer medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Blood Pharming of Red Cells.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2026Review
- The oncogene protein kinase PIM1 regulates mammalian erythroblast enucleation.Communications biology · 2025Article
- DDX41 resolves G-quadruplexes to maintain erythroid genome integrity and prevent cGAS-mediated cell death.Nature communications · 2025Article
- Stage-specific dual function: EZH2 regulates human erythropoiesis by eliciting histone and non-histone methylation.Haematologica · 2023Article
- Article
- RNA polymerase II pausing regulates chromatin organization in erythrocytes.Nature structural & molecular biology · 2023Article
- Heterochromatin rewiring and domain disruption-mediated chromatin compaction during erythropoiesis.Nature structural & molecular biology · 2023Article
- Article
- The inner nuclear membrane protein NEMP1 supports nuclear envelope openings and enucleation of erythroblasts.PLoS biology · 2022Article
- Epigenetic and Transcriptional Control of Erythropoiesis.Frontiers in genetics · 2022Review
- Histone H2A.X phosphorylation and Caspase-Initiated Chromatin Condensation in late-stage erythropoiesis.Epigenetics & chromatin · 2021Article
- Review
- Proteomic/transcriptomic analysis of erythropoiesis.Current opinion in hematology · 2021Review
- Epigenetic modifiers in normal and aberrent erythropoeisis.Seminars in hematology · 2021Review
- A new role of glutathione peroxidase 4 during human erythroblast enucleation.Blood advances · 2020Article
- Comprehensive proteomic analysis of murine terminal erythroid differentiation.Blood advances · 2020Article
- Biological basis for efficacy of activin receptor ligand traps in myelodysplastic syndromes.The Journal of clinical investigation · 2020Review
- Disruption of erythroid nuclear opening and histone release in myelodysplastic syndromes.Cancer medicine · 2019Article
- Circulating erythroblast abnormality associated with systemic pathologies may indicate bone marrow damage.Journal of circulating biomarkersArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Mammalian terminal erythropoiesis involves several characteristic phenomena including chromatin condensation and enucleation. One of the newly identified features of terminal erythropoiesis in mouse is a dynamic nuclear opening and histone release process, which is required for chromatin condensation. However, it is unclear whether the same feature is present in human. Here, we use an in vitro human CD34-positive hematopoietic stem and progenitor cell culture system and reveal that nuclear openings and histone release are also identified during human terminal erythropoiesis. In contrast to mouse in which each erythroblast contains a single opening, multiple nuclear openings are present in human erythroblast, particularly during the late-stage differentiation. The nuclear opening and histone release process is mediated by caspase-3. Inhibition of caspase-3 blocks nuclear opening, histone release, chromatin condensation, and terminal differentiation. We confirm the finding of histone cytosolic release in paraffin-embedded human bone marrow in vivo. Importantly, we find that patients with myelodysplastic syndrome (MDS) exhibit significant defects in histone release in the dysplastic erythroblasts. Our results reveal developmentally conserved nuclear envelop and histone dynamic changes in human terminal erythropoiesis and indicate that disruption of the histone release process plays a critical role in the pathogenesis of dyserythropoiesis in MDS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.