ArticleBrain and behavior2019
Prediction of early response to overall treatment for schizophrenia: A functional magnetic resonance imaging study.
Article in Brain and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Increased regional homogeneity modulated by metacognitive training predicts therapeutic efficacy in patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2021Trial
- Toward precision medicine: can neuroimaging prospectively predict early treatment outcomes in schizophrenia spectrum disorders? A systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2026Review
- Prediction of treatment responsiveness to home-based transcranial photobiomodulation (tPBM) intervention for cognitive decline using fNIRS concurrently recorded during tPBM.Frontiers in aging neuroscience · 2026Article
- Cerebellar-Cortical Connectivity and Prediction of Antipsychotic Treatment Response in First-Episode Psychosis.Schizophrenia bulletin · 2025Article
- Prediction of antipsychotic drug efficacy for schizophrenia treatment based on neural features of the resting-state functional connectome.Translational psychiatry · 2025Article
- Imaging Biomarker Studies of Antipsychotic-Naïve First-Episode Schizophrenia in China: Progress and Future Directions.Schizophrenia bulletin · 2025Review
- Multi-feature fusion RFE random forest for schizophrenia classification and treatment response prediction.Scientific reports · 2025Article
- Electrophysiological Markers Predicting Antipsychotic Treatment Response in Patients with Schizophrenia: A Retrospective Study.Neuropsychiatric disease and treatment · 2024Article
- Frontal lobe fALFF measured from resting-state fMRI as a prognostic biomarker in first-episode psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Schizophrenia: A Narrative Review of Etiopathogenetic, Diagnostic and Treatment Aspects.Journal of clinical medicine · 2022Article
- Functional Integration and Segregation in a Multilayer Network Model of Patients with Schizophrenia.Brain sciences · 2022Article
- Predicting Treatment Response in Schizophrenia With Magnetic Resonance Imaging and Polygenic Risk Score.Frontiers in genetics · 2022Article
- Atypical Antipsychotics Mediate Dynamics of Intrinsic Brain Activity in Early-Stage Schizophrenia? A Preliminary Study.Psychiatry investigation · 2021Article
- Magnetic Resonance Imaging-Guided and Navigated Individualized Repetitive Transcranial Magnetic Stimulation for Cognitive Impairment in Schizophrenia.Neuroscience bulletin · 2021Article
- Neuroimaging Biomarkers in Schizophrenia.The American journal of psychiatry · 2021Review
- Thalamus Radiomics-Based Disease Identification and Prediction of Early Treatment Response for Schizophrenia.Frontiers in neuroscience · 2021Article
- A Multimodal Fusion Analysis of Pretreatment Anatomical and Functional Cortical Abnormalities in Responsive and Non-responsive Schizophrenia.Frontiers in psychiatry · 2021Article
- Increased Homotopic Connectivity in the Prefrontal Cortex Modulated by Olanzapine Predicts Therapeutic Efficacy in Patients with Schizophrenia.Neural plasticity · 2021Observational
- The Association Between Lentiform Nucleus Function and Cognitive Impairments in Schizophrenia.Frontiers in human neuroscience · 2021Article
- Neuroimaging in Schizophrenia.Neuroimaging clinics of North America · 2020Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionTreatment response at an early stage of schizophrenia is of considerable value with regard to future management of the disorder; however, there are currently no biomarkers that can inform physicians about the likelihood of response. OBJECTS: We aim to develop and validate regional brain activity derived from functional magnetic resonance imaging (fMRI) as a potential signature to predict early treatment response in schizophrenia.
methodsAmplitude of low-frequency fluctuation (ALFF) was measured at the start of the first/single episode resulting in hospitalization. Inpatients were included in a principal dataset (n = 79) and a replication dataset (n = 44). Two groups of healthy controls (n = 87; n = 106) were also recruited for each dataset. The clinical response was assessed at discharge from the hospital. The predictive capacity of normalized ALFF in patients by healthy controls, ALFF
resultsIn the principal dataset, responders exhibited increased baseline ALFF in the left postcentral gyrus/inferior parietal lobule relative to non-responders. ALFF
conclusionsBaseline regional activity of the brain seems to be predictive of early response to treatment for schizophrenia. This study shows that psycho-neuroimaging holds promise for influencing the clinical treatment and management of schizophrenia.
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