ArticleJournal of biophotonics2019
Differential responses of myoblasts and myotubes to photobiomodulation are associated with mitochondrial number.
Article in Journal of biophotonics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effects of low-level laser therapy on reducing pain, edema, and trismus after orthognathic surgery: a systematic review.Lasers in medical science · 2022Pooled it
- Photobiomodulation does not improve anaerobic performance in well-trained cyclists.Lasers in medical science · 2023Trial
- Efficacy and Safety of Photobiomodulation in MELAS: Protocol for a Series of N-of-1 Trials.Journal of clinical medicine · 2025Article
- Article
- Assessing the Impact of High Photon Energy Wavelengths on the Treatment of Chronic Neck and Shoulder Pain.Evidence-based complementary and alternative medicine : eCAM · 2023Article
- Photobiomodulation in 3D tissue engineering.Journal of biomedical optics · 2022Article
- Photobiomodulation of oral fibroblasts stimulated with periodontal pathogens.Lasers in medical science · 2021Article
- Revisiting the role of mitochondria in spinal muscular atrophy.Cellular and molecular life sciences : CMLS · 2021Review
- Wavelength- and irradiance-dependent changes in intracellular nitric oxide level.Journal of biomedical optics · 2020Article
- Under the spotlight: mechanisms of photobiomodulation concentrating on blue and green light.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2019Article
- Differential responses of myoblasts and myotubes to photobiomodulation are associated with mitochondrial number.Journal of biophotonics · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
objectivePhotobiomodulation (PBM) is the application of light to promote tissue healing. Current indications suggest PBM induces its beneficial effects in vivo through upregulation of mitochondrial activity. However, how mitochondrial content influences such PBM responses have yet to be evaluated. Hence, the current study assessed the biological response of cells to PBM with varying mitochondrial contents.
methodsDNA was isolated from myoblasts and myotubes (differentiated myoblasts), and mitochondrial DNA (mtDNA) was amplified and quantified using a microplate assay. Cells were seeded in 96-wellplates, incubated overnight and subsequently irradiated using a light-emitting diode array (400, 450, 525, 660, 740, 810, 830 and white light, 24 mW/cm
resultsMyotubes exhibited mtDNA levels 86% greater than myoblasts (P < 0.001). Irradiation of myotubes at 400, 450 or 810 nm induced 53%, 29% and 47% increases (relative to non-irradiated control) in maximal respiratory rates, respectively (P < 0.001). Conversely, irradiation of myoblasts at 400 or 450 nm had no significant effect on maximal respiratory rates.
conclusionThis study suggests that mitochondrial content may influence cellular responses to PBM and as such explain the variability of PBM responses seen in the literature.
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