Evidence map›Paper›PMID 30701650›Full record

ReviewAngewandte Chemie (International ed. in English)2019

Selective Arene Hydrogenation for Direct Access to Saturated Carbo- and Heterocycles.

Mario P Wiesenfeldt, Zackaria Nairoukh, Toryn Dalton, Frank Glorius

Abstract readReview
In one paragraph

Review in Angewandte Chemie (International ed. in English), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed.

  1. The Palladium(IV)-Centered Hexatungstate Ion [PdChemistry (Weinheim an der Bergstrasse, Germany) · 2026
    Article
  2. Iridium-Catalyzed Ionic Hydrogenation of Multi-Aza Heterocycles.Angewandte Chemie (International ed. in English) · 2026
    Article
  3. Review
  4. Pd/C-Catalyzed Hydrogenation of CFAngewandte Chemie (International ed. in English) · 2026
    Article
  5. Article
  6. Article
  7. Dynamic Dual Role as Cationic CuOrganic letters · 2026
    Article
  8. Electrochemical Hydrogenation of Aza-Arenes Using HJournal of the American Chemical Society · 2026
    Article
  9. Chemical science · 2026
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Palladium-Catalyzed Dual CspAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Mario P WiesenfeldtOrganisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.ORCID 0000-0002-7142-9336
Zackaria NairoukhOrganisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.ORCID 0000-0001-8443-4292
Toryn DaltonOrganisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.ORCID 0000-0003-1580-6480
Frank GloriusOrganisch-Chemisches Institut, Westfälische Wilhelms-Universität Münster, Corrensstrasse 40, 48149, Münster, Germany.ORCID 0000-0002-0648-956X

Funding

Deutsche Forschungsgemeinschaft Leibniz AwardDeutsche Forschungsgemeinschaft SFB858Hans-Jensen-Minerva FoundationStudienstiftung des Deutschen Volkes
6 · The paper itself

Abstract

Arene hydrogenation provides direct access to saturated carbo- and heterocycles and thus its strategic application may be used to shorten synthetic routes. This powerful transformation is widely applied in industry and is expected to facilitate major breakthroughs in the applied sciences. The ability to overcome aromaticity while controlling diastereo-, enantio-, and chemoselectivity is central to the use of hydrogenation in the preparation of complex molecules. In general, the hydrogenation of multisubstituted arenes yields predominantly the cis isomer. Enantiocontrol is imparted by chiral auxiliaries, Brønsted acids, or transition-metal catalysts. Recent studies have demonstrated that highly chemoselective transformations are possible. Such methods and the underlying strategies are reviewed herein, with an emphasis on synthetically useful examples that employ readily available catalysts.

Indexed as

arene hydrogenationchemoselectivitycycloalkanesheterocyclesstereoselectivity

Identifiers

PMID30701650
PMCPMC6697539

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.