Evidence map›Paper›PMID 30701572›Full record

ArticleThe International journal of eating disorders2019

A test of the DSM-5 severity specifier for bulimia nervosa in adolescents: Can we anticipate clinical treatment outcomes?

Sasha Gorrell, Lisa Hail, Kathryn Kinasz, Lindsey Bruett, Sarah Forsberg, Kevin Delucchi, James Lock, Daniel Le Grange

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The International journal of eating disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06213883 (Characterizing Acute Exercise Response in Restrictive Eating Disorders), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06213883 nacompletednot on this mapstarted 2023, after this paper: background citation

Characterizing Acute Exercise Response in Restrictive Eating Disorders

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2023 to 2025Enrolled74ConditionsEating DisordersArmsBiobehavioral Response to in-lab exposure to physical activity
3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Remission in adolescents with bulimia nervosa: Empirical evaluation of current conceptual models.European eating disorders review : the journal of the Eating Disorders Association · 2020
    Trial
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sasha GorrellDepartment of Psychiatry, University of California, San Francisco, California.ORCID 0000-0002-8861-8547
Lisa HailDepartment of Psychiatry, University of California, San Francisco, California.
Kathryn KinaszDepartment of Psychiatry, University of California, San Francisco, California.
Lindsey BruettDepartment of Psychiatry, University of California, San Francisco, California.
Sarah ForsbergDepartment of Psychiatry, University of California, San Francisco, California.
Kevin DelucchiDepartment of Psychiatry, University of California, San Francisco, California.
James LockDepartment of Psychiatry and Behavioral Sciences, Stanford University, Stanford, California.ORCID 0000-0002-5169-1484
Daniel Le GrangeDepartment of Psychiatry, University of California, San Francisco, California.ORCID 0000-0001-7293-9496

Funding

CLINICAL SERVICES RESEARCH TRAINING PROGRAMT32MH018261 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaja Zabrina LeWinn, Rachel L. Loewy · 1985 to 2026
$7.0M
1/2-Treatment of Bulimic AdolescentsR01MH079978 · NIMH · STANFORD UNIVERSITY · PI LOCK, JAMES D · 2008 to 2012
$2.2M
2/2 Predictors and Course of Postpartum Obsessions and CompulsionsR01MH118261 · NIMH · JOHNS HOPKINS UNIVERSITY · PI NESTADT, GERALD · 2019 to 2023
$2.1M
2/2-Treatment of Adolescent BulimicsR01MH079979 · NIMH · UNIVERSITY OF CHICAGO · PI LE GRANGE, DANIEL · 2008 to 2012
$1.5M
National Institute of Mental Health Grant R01-MH-079978National Institute of Mental Health Grant R01-MH-079979NIH HHS MH0118261-33NIMH NIH HHS R01 MH118261NIMH NIH HHS T32 MH018261
6 · The paper itself

Abstract

objectiveThis study tested clinical utility of the DSM-5 severity specifier for bulimia nervosa (BN) in predicting treatment response among adolescents (N = 110) within a randomized clinical trial of two psychosocial treatments.

methodAnalyses grouped individuals meeting criteria for BN diagnosis by baseline severity, per DSM-5. Associations among baseline severity classification and BN behavior (i.e., binge eating and compensatory behavior) and eating disorder examination (EDE) Global scores at end-of-treatment (EOT), 6- and 12-month follow-up were examined.

resultsAssociations between severity categories with BN symptoms were not significant at EOT, or follow-up. Test for linear trend in BN behavior was significant at EOT, F = 5.23, p = 0.02, without demonstrating a linear pattern. Relation between severity categories with EDE Global scores was significant at 6-month follow-up, F = 3.76, p = 0.01. Tests for linear trend in EDE Global scores were significant at EOT, F = 5.40, p = 0.02, and at 6 months, F = 10.73, p = 0.002, with the expected linear pattern. DISCUSSION: Findings suggest the DSM-5 BN severity specifier holds questionable utility in anticipating outpatient treatment response in adolescents with BN. The specifier may have improved ability to predict attitudinal rather than behavioral treatment outcomes.

Indexed as

Diagnostic and Statistical Manual of Mental DisordersAdolescentBulimia NervosaChildFemaleHumansMaleTreatment Outcomeadolescentsbulimia nervosacognitive behavioral therapyfamily-based treatmentseverity classificationtreatment outcome

Identifiers

PMID30701572
PMCPMC6499649

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.