Evidence map›Paper›PMID 30701416›Full record

ArticleMolecular neurobiology2019

Fingolimod Suppresses the Proinflammatory Status of Interferon-γ-Activated Cultured Rat Astrocytes.

Saša Trkov Bobnar, Matjaž Stenovec, Katarina Miš, Sergej Pirkmajer, Robert Zorec

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Multiple Sclerosis: Inflammatory and Neuroglial Aspects.Current issues in molecular biology · 2023
    Review
  3. Observational
  4. Review
  5. Review
  6. Functional imaging of astrocyte activity.Neural regeneration research · 2021
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Saša Trkov BobnarLaboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000, Ljubljana, Slovenia.
Matjaž StenovecLaboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000, Ljubljana, Slovenia.
Katarina MišLaboratory for Molecular Neurobiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000, Ljubljana, Slovenia.
Sergej PirkmajerLaboratory for Molecular Neurobiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000, Ljubljana, Slovenia.
Robert ZorecLaboratory of Neuroendocrinology-Molecular Cell Physiology, Institute of Pathophysiology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000, Ljubljana, Slovenia. robert.zorec@mf.uni-lj.si.ORCID http://orcid.org/0000-0002-7478-3875

Funding

GLYCOSYLTRANSFERASES IN IMMUNE RECOGNITIONF32CA007605 · NCI · JOHNS HOPKINS UNIVERSITY · PI REICHNER, JONATHAN S · 1985 to 1985
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COST Action BM1002EU COST Action CM1207 - EuroCellNetEU COST Action CM1207 - GLISTENJavna Agencija za Raziskovalno Dejavnost RS J3 6789Javna Agencija za Raziskovalno Dejavnost RS J3 6790Javna Agencija za Raziskovalno Dejavnost RS J3 7605Javna Agencija za Raziskovalno Dejavnost RS P3-0043Javna Agencija za Raziskovalno Dejavnost RS P3-310
6 · The paper itself

Abstract

Astroglia, the primary homeostatic cells of the central nervous system, play an important role in neuroinflammation. They act as facultative immunocompetent antigen-presenting cells (APCs), expressing major histocompatibility complex (MHC) class II antigens upon activation with interferon (IFN)-γ and possibly other proinflammatory cytokines that are upregulated in disease states, including multiple sclerosis (MS). We characterized the anti-inflammatory effects of fingolimod (FTY720), an established drug for MS, and its phosphorylated metabolite (FTY720-P) in IFN-γ-activated cultured rat astrocytes. The expression of MHC class II compartments, β

Indexed as

Adenosine TriphosphateAnimalsAstrocytesCell CountCells, CulturedCytoplasmic VesiclesDextransFemaleFingolimod HydrochlorideHistocompatibility Antigens Class IIInflammationInterferon-gammaRats, WistarReceptors, Adrenergic, beta-2Transcription Factor RelAAdenosine TriphosphateDextransFingolimod HydrochlorideHistocompatibility Antigens Class IIInterferon-gammaReceptors, Adrenergic, beta-2Transcription Factor RelAAntigen-presenting cells (APCs)AstrocytesFingolimodInterferon-γMajor histocompatibility complex (MHC) class II molecules

Identifiers

PMID30701416

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.