Trial reportSurgical endoscopy2019
Open versus minimally invasive liver surgery for colorectal liver metastases (LapOpHuva): a prospective randomized controlled trial.
Trial report in Surgical endoscopy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02727179 (Prospective and Randomized Study Comparing Open vs Laparoscopic Liver Surgery for Colorectal Liver Metastases), which is not on this map. Cited by 78 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective and Randomized Study Comparing Open vs Laparoscopic Liver Surgery for Colorectal Liver Metastases
Who cites it
78 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Comparing Open, Laparoscopic and Robotic Liver Resection for Metastatic Colorectal Cancer-A Systematic Review and Network Meta-Analysis.Journal of surgical oncology · 2025Pooled it
- Laparoscopic versus open liver resection for colorectal liver metastasis: an umbrella review.Frontiers in oncology · 2024Pooled it
- SAGES/AHPBA guidelines for the use of minimally invasive surgery for the surgical treatment of colorectal liver metastases (CRLM).Surgical endoscopy · 2023Pooled it
- Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations 2022.World journal of surgery · 2023Pooled it
- Minimally invasive versus open hepatectomy for the resection of colorectal liver metastases: a systematic review and meta-analysis.Surgical endoscopy · 2022Pooled it
- [Evidence of minimally invasive oncological surgery of the liver].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2021Pooled it
- Laparoscopic versus open hemihepatectomy: does side matter? A post-hoc analysis of the ORANGE II PLUS randomized controlled trial.Surgical endoscopy · 2026Trial
- Laparoscopic Versus Open Hemihepatectomy: The ORANGE II PLUS Multicenter Randomized Controlled Trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2024Trial
- Challenges and catalysators in building a robotic HPB program: the experience of a tertiary cancer center.Updates in surgery · 2026Article
- Conversion in Minimally Invasive Liver Surgery: The Impact of Conversion Urgency and Surgical Approach.Annals of surgical oncology · 2026Article
- Robotic hepatectomy across IWATE difficulty levels: a single-center experience of the first 100 cases.Journal of robotic surgery · 2026Article
- Refining the boundaries of resectability for colorectal cancer liver metastases with extrahepatic disease-surgical lessons from a nationwide analysis.Hepatobiliary surgery and nutrition · 2026Article
- Robotic versus laparoscopic hepatectomy: an umbrella review of systematic reviews and meta-analyses.Surgery in practice and science · 2026Review
- Robotic liver resection in minimally invasive expert centers is associated with a very low rate of bile leakage: results from a national multicenter cohort.Journal of robotic surgery · 2026Observational
- The Cost of Progress that Pays Off.Annals of surgical oncology · 2026Article
- Robotic right hepatectomy via an anterior approach: technical considerations for managing large hepatocellular carcinomas.Updates in surgery · 2026Article
- Article
- Postoperative outcomes with minimally invasive minor hepatectomy based on ECOG performance status - analysis of multi-institutional database.Surgical endoscopy · 2025Article
- Robotic liver approach facilitates one-month quality of life restoration before surgery.Journal of robotic surgery · 2025Article
- Laparoscopic resection combined with ablation for multiple colorectal liver metastases: a multicentre propensity-matched analysis.Surgical endoscopy · 2025Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo present surgical and oncological outcomes using a prospective and randomized trial (LapOpHuva, NCT02727179) comparing minimally invasive liver resection (LLR) versus open liver resection (OLR) in patients with colorectal liver metastases (CRLM).
methodsBetween February 2005 and March 2016, 204 selected patients with CRLM were randomized and 193 were included: LLR (n = 96) and OLR (n = 97). The primary endpoint was to compare postoperative morbidity. Other secondary endpoints were oncological outcomes, use of the Pringle maneuver, surgical time, blood losses, transfusions, hospital stay, mortality and OS, and disease-free survival (DFS) at 3, 5, and 7 years.
resultsLLR presented with lower global morbidity (11.5% vs. 23.7%, p = 0.025) but with similar severe complications. Long-term survival outcomes were similar in both groups. The cumulative 1-, 3-, 5-, 7-year OS for LLR and OLR were 92.5%, 71.5%, 49.3%, 35.6% versus 93.6%, 69.7%, 47.4%, 35.5%, respectively (log-rank = 0.047, p = 0.82). DFS for LLR and OLR was 72.7%, 33.5%, 22.7%, and 20.8% versus 61.6%, 27.2%, 23.9%, and 17.9%, respectively (log-rank = 1.427, p = 0.23). LLR involved more use of the Pringle maneuver (15.5% vs. 30.2%, p = 0.025) and a shorter hospital stay (4 vs. 6 days, p < 0.001). There were no differences regarding surgical time, blood losses, transfusion, and mortality.
conclusionsIn selected patients with CRLM, LLR presents similar oncological outcomes with the advantages of the short-term results associated with LLR.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.