ReviewCurrent treatment options in neurology2019
Sleep Abnormalities in Multiple Sclerosis.
Review in Current treatment options in neurology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Pooled it
- Subjective sleep disturbances are associated with reduced MRI-derived perivascular-space diffusivity in multiple sclerosis.Journal of neurology · 2026Article
- Sleep Macrostructure, Cyclic Alternating Pattern and CSF Cytokines in De Novo Relapsing-Remitting Multiple Sclerosis: A Controlled Polysomnographic Study.Journal of sleep research · 2026Article
- Association between fatigue and functional status among patients with multiple sclerosis.Frontiers in neurology · 2026Article
- Prevalence and Associations of Poor Sleep in Patients with Relapsing-Remitting Multiple Sclerosis on Disease-Modifying Therapy.Journal of clinical medicine · 2025Article
- Sleep disorders and associated factors in multiple sclerosis patients: a cross-sectional study in Iran.BMC neurology · 2025Article
- Effect of Telerehabilitation Exercise Program on Sleep Quality and Fatigue in Individuals With Multiple Sclerosis.Annals of rehabilitation medicine · 2025Article
- Sleep disorders in patients with multiple sclerosis.BMC neurology · 2025Article
- Sleep Disorders in a Sample of Patients with Pediatric-Onset Multiple Sclerosis: Focus on Restless Legs Syndrome.Journal of clinical medicine · 2025Article
- Relationship between sleep disorders and information processing speed in multiple sclerosis.Clinics (Sao Paulo, Brazil) · 2025Article
- Characteristics and correlations of sleep disorders in patients with relapsing-remitting multiple sclerosis in China: a cross-sectional study.Frontiers in neurology · 2025Article
- Sleep Disorders and Optic Neuritis Risk in Multiple Sclerosis: A Retrospective Cohort Study.Cureus · 2025Article
- German translation, cultural adaptation for Austria, and validation of the Neurological Sleep Index-Multiple Sclerosis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Restless legs syndrome in multiple sclerosis: uncovering prevalence and clinical aspects.Sleep & breathing = Schlaf & Atmung · 2024Article
- Exploring Sleep Architecture in Polish Patients with Multiple Sclerosis: A Polysomnography Study.Brain sciences · 2024Article
- The relationship between sleep quality and gait in people with multiple sclerosis: A pilot study.Hong Kong physiotherapy journal : official publication of the Hong Kong Physiotherapy Association Limited = Wu li chih liao · 2024Article
- The multidimensional sleep health of individuals with multiple sclerosis and Huntington's disease and healthy controls.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Sleep Disorders and Fatigue among Patients with MS: The Role of Depression, Stress, and Anxiety.Neurology research international · 2024Article
- Article
- Sleep Disturbances in Autoimmune Neurological Diseases.Current neurology and neuroscience reports · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThis review summarizes the most well-documented sleep disorders seen in patients with multiple sclerosis (MS), with a special focus on the impact on quality of life. RECENT
findingsSleep abnormalities in patients with MS are a multifactorial and relatively complex issue affecting approximately 60% of the patients while the pathophysiology of these symptoms is not fully understood. Circadian rhythm disorders and increased levels of pro-inflammatory cytokines have been recognized as potential players in affecting sleep homeostasis in MS patients. Medication-related side effects such as in immunotherapy and other factors such as lesion load can contribute to the disruption of normal sleep patterns. Most frequently encountered sleep disorders are insomnia, sleep-related movement disorders, sleep-related breathing disorders, and circadian rhythm disorders affecting both adults and paediatric MS populations. Aetiology still remains unknown with treatment options focusing on behavioural cognitive therapy and lifestyle modification including improvement in sleep hygiene as well as melatonin supplementation. Given MS prevalence is still rising affecting millions of people, more personalized medicine applications should possibly form the key approach for improving patients' quality of life and quality years.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.