ArticleClinical research in cardiology : official journal of the German Cardiac Society2019
Stress T1-mapping cardiovascular magnetic resonance imaging and inducible myocardial ischemia.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Stress T1 mapping and quantitative perfusion cardiovascular magnetic resonance in patients with suspected obstructive coronary artery disease.European heart journal. Cardiovascular Imaging · 2025Article
- Potential of non-contrast stress T1 mapping for the assessment of myocardial injury in hypertrophic cardiomyopathy.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2023Article
- Dynamic Cardiac Magnetic Resonance Fingerprinting During Vasoactive Breathing Maneuvers: First Results.Journal of cardiovascular imaging · 2023Article
- Cardiovascular Magnetic Resonance Parametric Mapping Techniques for the Assessment of Chronic Coronary Syndromes.Journal of cardiovascular development and disease · 2022Review
- Non-contrast myocardial perfusion in rest and exercise stress using systolic flow-sensitive alternating inversion recovery.Magma (New York, N.Y.) · 2022Article
- Compact MR-compatible ergometer and its application in cardiac MR under exercise stress: A preliminary study.Magnetic resonance in medicine · 2022Article
- Native T1 mapping for differentiating the histopathologic type, grade, and stage of rectal adenocarcinoma: a pilot study.Cancer imaging : the official publication of the International Cancer Imaging Society · 2022Article
- Myocardial blood flow is the dominant factor influencing cardiac magnetic resonance adenosine stress T2.NMR in biomedicine · 2022Article
- Stress CMR T1-mapping technique for assessment of coronary microvascular dysfunction in a rabbit model of type II diabetes mellitus: Validation against histopathologic changes.Frontiers in cardiovascular medicine · 2022Article
- Ferumoxytol-enhanced magnetic resonance T1 reactivity for depiction of myocardial hypoperfusion.NMR in biomedicine · 2021Article
- Cardiac stress T1-mapping response and extracellular volume stability of MOLLI-based T1-mapping methods.Scientific reports · 2021Article
- Cardiovascular magnetic resonance stress and rest T1-mapping using regadenoson for detection of ischemic heart disease compared to healthy controls.International journal of cardiology · 2021Article
- Cardiac magnetic resonance fingerprinting: Trends in technical development and potential clinical applications.Progress in nuclear magnetic resonance spectroscopy · 2021Review
- Clinical, angiographic and echocardiographic correlates of epicardial and microvascular spasm in patients with myocardial ischaemia and non-obstructive coronary arteries.Clinical research in cardiology : official journal of the German Cardiac Society · 2020 · on this mapArticle
- FIFA World Cup 2018: effect of emotional stress on conventional heart rate variability metrics.Clinical research in cardiology : official journal of the German Cardiac Society · 2020Article
- Myocardial T1 and ECV Measurement: Underlying Concepts and Technical Considerations.JACC. Cardiovascular imaging · 2019Review
- Stress T1 mapping for the detection of obstructive coronary artery disease: a prospective diagnostic accuracy study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceArticle
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13 authors.
Funding
Abstract
backgroundAlterations in native myocardial T1 under vasodilation stress ("T1 reactivity") were recently proposed as a non-contrast cardiovascular magnetic resonance (CMR) method to detect myocardial ischemia. This study evaluated the performance of a segmental, truly non-contrast stress T1 mapping CMR approach to detect inducible ischemia. METHODS AND
resultsOne-hundred patients with suspected/known coronary artery disease underwent CMR at 3.0 or 1.5 T. T1 mapping was performed using the 5s(3s)3s-modified look-locker inversion-recovery (MOLLI) sequence at rest and under regadenoson stress. We defined T1 reactivity as the change in native T1 from rest to stress (1) in the 16-segment AHA model independent from perfusion images and (2) in focal regions of interest that were copied from perfusion images to T1 maps. We compared T1 reactivity between segments/regions with inducible ischemia, scar, and remote myocardium for both approaches. Segmental T1 reactivity was significantly lower in segments including inducible ischemia [- 1.15 (95% CI, - 2.16 to - 0.14)%] compared to remote segments [2.49 (95% CI, 1.87 to 3.11)%; p < 0.001]. Focal T1 reactivity was also significantly lower [- 2.65 (95% CI, - 3.84 to - 1.46)%] in regions with stress-perfusion defects compared to remote regions [4.72 (95% CI, 3.90 to 5.54)%; p < 0.001]. However, the performance of segmental T1 reactivity to depict inducible ischemia was significantly inferior compared to the focal approach (AUCs 0.68 versus 0.85; p < 0.0001).
conclusionsMyocardium with inducible ischemia is characterized by the absence of significant T1 reactivity, but a clinically applicable approach for truly non-contrast stress T1 mapping remains to be determined.
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