Evidence map›Paper›PMID 30701294›Full record

Observational studyIntensive care medicine2019

Tailored multicomponent program for discomfort reduction in critically ill patients may decrease post-traumatic stress disorder in general ICU survivors at 1 year.

Pierre Kalfon, Marine Alessandrini, Mohamed Boucekine, Stéphanie Renoult, Marie-Agnès Geantot, Stéphanie Deparis-Dusautois, Audrey Berric, Olivier Collange, Bernard Floccard, Olivier Mimoz and 23 more

2 registry-linked trialsAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Intensive care medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02762409 completednot on this map

Improve the Quality of Life After a Hospitalization in Critical Care Thanks to a Program of Prevention of Discomforts Perceived by the Patients of Critical Care Base on Targeted Measures

Typeobservational_patient_registrySponsorCentre Hospitalier of ChartresRan2015 to 2016Enrolled1,006ConditionsDepression, Depression SymptomsArmsexperimental, control
NCT03991611 naunknown statusnot on this map

Tailored Multicomponent Program for Discomfort Reduction in Critically il Patients May Decrease Post-traumatic Stress Disorder in General ICU Survivors at One Year

TypeinterventionalSponsorCentre Hospitalier of ChartresRan2019 to 2023Enrolled3,312ConditionsCritical IllnessArmsAdministration of the IPREA3 questionnaire, Immediate feedback through electronic reminder messages, Targeted interventions in each ICU to reduce discomforts, 6 months follow-up to assess the prevalence of PTSD symptoms, 1 year follow-up to assess psychiatric morbidity
3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 19 institutions in 2 countries.

Pierre KalfonRéanimation Polyvalente, Hôpital Louis Pasteur, Hôpitaux de Chartres, 28018, Le Coudray, France. pkalfon@ch-chartres.fr.ORCID 0000-0002-0095-8759
Marine AlessandriniUnité de recherche CEReSS-EA3279, Aix-Marseille Université, Marseille, France.
Mohamed BoucekineUnité de recherche CEReSS-EA3279, Aix-Marseille Université, Marseille, France.
Stéphanie RenoultRéanimation, Clinique Ambroise Paré, Neuilly/Seine, France.
Marie-Agnès GeantotDépartement d'Anesthésie Réanimation, CHU Dijon Bourgogne, Dijon, France.
Stéphanie Deparis-DusautoisRéanimation, CH Troyes, Troyes, France.
Audrey BerricRéanimation polyvalente, Centre Hospitalier Intercommunal Toulon/La Seyne sur mer, Toulon, France.
Olivier CollangeRéanimation chirurgicale polyvalente, Hôpital Civil, CHU Strasbourg, Strasbourg, France.
Bernard FloccardRéanimation polyvalente, CHU Edouard Herriot, Hospices Civils de Lyon, Lyon, France.
Olivier MimozRéanimation chirurgicale, CHU La Milétrie, Poitiers, France.
Amour JulienRéanimation de chirurgie cardiaque, CHU Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris (AP-HP), Paris, France.
René RobertRéanimation médicale, CHU La Milétrie, Poitiers, France.
Juliette AudibertRéanimation Polyvalente, Hôpital Louis Pasteur, Hôpitaux de Chartres, 28018, Le Coudray, France.
Anne RenaultRéanimation médicale, CHU Brest, Brest, France.
Arnaud FollinRéanimation Chirurgicale, Hôpital Européen Georges Pompidou, AP-HP, Paris, France.
Didier TheveninRéanimation, CH Lens, Lens, France.
Nathalie RevelRéanimation Médico-Chirurgicale, Hôpital Pasteur, CHU Nice, Nice, France.
Marion VenotRéanimation Médicale, CHU Saint-Louis, AP-HP, Paris, France.
René-Gilles PatrigeonRéanimation, CH Auxerre, Auxerre, France.
Thomas SignouretRéanimation, Hôpital Européen de Marseille, Marseille, France.
Mélanie FromentinRéanimation chirurgicale, CHU Cochin, AP-HP, Paris, France.
Tarek SharsharRéanimation médicale adulte, CHU Raymond Poincaré, AP-HP, Paris, France.
Coralie VigneRéanimation chirurgicale, CHU Hôpital Nord, Assistance Publique-Hôpitaux de Marseille, Marseille, France.
Julien PottecherRéanimation chirurgicale, Hôpital Hautepierre, CHU Strasbourg, Strasbourg, France.
Quentin LevratGroupe Hospitalier de La Rochelle-Ré-Aunis, La Rochelle, France.
Achille SossouRéanimation, CH Émile Roux, Le Puy-En-Velay, France.
Maïté Garrouste-OrgeasMédecine intensive et réanimation, Groupe Hospitalier Paris Saint-Joseph, Paris, France.
Jean-Pierre QuenotRéanimation médicale, CHU Dijon Bourgogne, Dijon, France.
Claire BoulleRéanimation, CH Douai, Douai, France.
Elie AzoulayRéanimation Médicale, CHU Saint-Louis, AP-HP, Paris, France.
Karine BaumstarckUnité de recherche CEReSS-EA3279, Aix-Marseille Université, Marseille, France.
Pascal AuquierUnité de recherche CEReSS-EA3279, Aix-Marseille Université, Marseille, France.
IPREA-AQVAR Study Group
Assistance Publique – Hôpitaux de Paris · FRAix-Marseille Université · FRCHU Dijon Bourgogne · FRCentre Hospitalier de Douai · FRCentre hospitalier Emile Roux · FRHôpital Cochin · FRSorbonne Université · FRUniversité Claude Bernard Lyon 1 · FRCentre Hospitalier de La Rochelle · FRCentre Hospitalier de Lens · FRCentre Hospitalier de Troyes · FRCeres · USHôpital Européen · FRHôpital Européen Georges-Pompidou · FRHôpital Nord · FRHôpitaux Universitaires de Strasbourg · FRHospices Civils de Lyon · FRLes Hôpitaux de Chartres · FRUniversité de Poitiers · FR

Funding

French Ministry of Health PREPS-15-000183
6 · The paper itself

Abstract

purposeReducing discomfort in the intensive care unit (ICU) should have a positive effect on long-term outcomes. This study assessed whether a tailored multicomponent program for discomfort reduction was effective in reducing post-traumatic stress disorder (PTSD) symptoms at 1 year in general ICU survivors.

methodsThis study is a prospective observational comparative effectiveness cohort study involving 30 ICUs. It was an extension of the IPREA3 study, a cluster-randomized controlled trial designed to assess the efficacy of a tailored multicomponent program to reduce discomfort in critically ill patients. The program included assessment of ICU-related self-perceived discomforts, immediate and monthly feedback to the healthcare team, and site-specific tailored interventions. The exposure was the implementation of this program. The eligible patients were exposed versus unexposed general adult ICU survivors. The prevalence of substantial PTSD symptoms at 1 year was assessed based on the Impact of Event Scale-Revised (IES-R).

resultsOf the 1537 ICU survivors included in the study, 475 unexposed patients and 344 exposed patients had follow-up data at 1 year: 57 (12.0%) and 21 (6.1%) presented with PTSD at 1 year, respectively (p = 0.004). Considering the clustering and after adjusting for age, gender, McCabe classification, and ICU-related self-perceived overall discomfort score, exposed patients were significantly less likely than unexposed patients to have substantial PTSD symptoms at 1 year (p = 0.015).

conclusionsImplementation of a tailored multicomponent program in the ICU that has proved to be effective for reducing self-perceived discomfort in general adult ICU survivors also reduced the prevalence of substantial PTSD symptoms at 1 year.

trial registrationClinicalTrials.gov identifier NCT02762409.

Indexed as

AdultAgedAged, 80 and overCohort StudiesCritical IllnessFemaleHospitalizationHumansIntensive Care UnitsMaleMiddle AgedPatient-Centered CarePatient ComfortProgram EvaluationProspective StudiesQuality of LifeCritical careDiscomfortICUPatient-reported outcomePost-traumatic stress disorderTailored program

Identifiers

PMID30701294
OpenAlexW2912196028

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.