Evidence map›Paper›PMID 30701286›Full record

ArticleArchives of toxicology2019

Evaluation of inhaled low-dose formaldehyde-induced DNA adducts and DNA-protein cross-links by liquid chromatography-tandem mass spectrometry.

Jiapeng Leng, Chih-Wei Liu, Hadley J Hartwell, Rui Yu, Yongquan Lai, Wanda M Bodnar, Kun Lu, James A Swenberg

Open access · greenAbstract read
In one paragraph

Article in Archives of toxicology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Formaldehyde and asthma: a plausibility?Archives of toxicology · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Effects of Gut Microbiome on Carcinogenic DNA Damage.Chemical research in toxicology · 2020
    Article
  16. Review
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jiapeng LengDepartment of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Chih-Wei LiuDepartment of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Hadley J HartwellDepartment of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Rui YuDepartment of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Yongquan LaiLovelace Respiratory Research Institute, Albuquerque, NM, 87108, USA.
Wanda M BodnarDepartment of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.
Kun LuDepartment of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. kunlu@unc.edu.
James A SwenbergDepartment of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. jswenber@email.unc.edu.
University of North Carolina at Chapel Hill · USLovelace Respiratory Research Institute · US

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Functional interaction between the gut microbiome and arsenic exposureR01ES024950 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LU, KUN · 2015 to 2019
$2.5M
NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES024950
6 · The paper itself

Abstract

As a widespread industrial chemical, formaldehyde carcinogenicity has been highly controversial. Meanwhile, formaldehyde is an essential metabolite in all living cells. Previously, we have demonstrated exogenous formaldehyde causes DNA adducts in a nonlinear manner between 0.7 and 15.2 ppm using [

Indexed as

AnimalsCarcinogensChromatography, High Pressure LiquidChromatography, LiquidDNA AdductsDose-Response Relationship, DrugFormaldehydeInhalation ExposureRatsTandem Mass SpectrometryToxicity TestsCarcinogensDNA AdductsFormaldehydeDNA adductsDNA damageDNA–protein crosslinksFormaldehydeMass spectrometry

Identifiers

PMID30701286
PMCPMC7839796
OpenAlexW2913452350

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.