ArticleFrontiers in bioengineering and biotechnology2018
Genetic Alterations That Do or Do Not Occur Naturally; Consequences for Genome Edited Organisms in the Context of Regulatory Oversight.
Article in Frontiers in bioengineering and biotechnology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed.
- Emerging applications of gene editing technologies for the development of climate-resilient crops.Frontiers in genome editing · 2025Review
- Mind the (CRISPR) gaps: The European Commission's proposal for the use of NGTs in the EU.EMBO reports · 2023Article
- Should we still worry about the safety of GMO foods? Why and why not? A review.Food science & nutrition · 2021Review
- Regulatory approaches for genome edited agricultural plants in select countries and jurisdictions around the world.Transgenic research · 2021Review
- Revisions to USDA biotechnology regulations: The SECURE rule.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Hotter, drier, CRISPR: the latest edit on climate change.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Review
- Regulation of Synthetic Biology: Developments Under the Convention on Biological Diversity and Its Protocols.Frontiers in bioengineering and biotechnology · 2020Review
- Politicizing the Precautionary Principle: Why Disregarding Facts Should Not Pass for Farsightedness.Frontiers in plant science · 2019Article
- The Judgment of the CJEU of 25 July 2018 on Mutagenesis: Interpretation and Interim Legislative Proposal.Frontiers in plant science · 2019Article
- Roads Forward for European GMO Policy-Uncertainties in Wake of ECJ Judgment Have to be Mitigated by Regulatory Reform.Frontiers in bioengineering and biotechnology · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability to successfully exploit genome edited organisms for the benefit of food security and the environment will essentially be determined by the extent to which these organisms fall under specific regulatory provisions. In many jurisdictions the answer to this question is considered to depend on the genetic characteristics of the edited organism, and whether the changes introduced in its genome do (or do not) occur naturally. We provide here a number of key considerations to assist with this evaluation as well as a guide of concrete examples of genetic alterations with an assessment of their natural occurrence. These examples support the conclusion that for many of the common types of alterations introduced by means of genome editing, the resulting organisms would not be subject to specific biosafety regulatory provisions whenever novelty of the genetic combination is a crucial determinant.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.