Evidence map›Paper›PMID 30701169›Full record

ArticleFrontiers in pediatrics2018

Diabetes Mellitus in a Patient With Lafora Disease: Possible Links With Pancreatic β-Cell Dysfunction and Insulin Resistance.

Ramona C Nicolescu, Sara Al-Khawaga, Berge A Minassian, Khalid Hussain

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Insulin and Autophagy in Neurodegeneration.Frontiers in neuroscience · 2019
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Ramona C NicolescuDivision of Endocrinology and Diabetes, Department of Pediatrics, University of Liège, Centre Hospitalier Régional de la Citadelle, Liège, Belgium.
Sara Al-KhawagaDivision of Endocrinology, Department of Pediatrics, Sidra Medicine Outpatient Clinic, Doha, Qatar.
Berge A MinassianDivision of Neurology, Department of Pediatrics, University of Texas Southwestern, Dallas, TX, United States.
Khalid HussainDivision of Endocrinology, Department of Pediatrics, Sidra Medicine Outpatient Clinic, Doha, Qatar.
The University of Texas Southwestern Medical Center · USUniversity of Liège · BE

Funding

Suppressing glycogen storage with small molecule inhibitors as a therapeutic approach to Lafora DiseaseP01NS097197 · NINDS · UNIVERSITY OF KENTUCKY · PI GAO, TIANYAN · 2016 to 2021
$9.0M
NINDS NIH HHS P01 NS097197
6 · The paper itself

Abstract

Lafora disease (LD) is a rare autosomal recessive disorder characterized by progressive myoclonic epilepsy followed by continuous neurological decline, culminating in death within 10 years. LD leads to accumulation of insoluble, abnormal, glycogen-like structures called Lafora bodies (LBs). It is caused by mutations in the gene encoding glycogen phosphatase (

Indexed as

diabetesEPM2AEPM2B/NHLRC1glycogen metabolisminsulin resistanceLafora disease

Identifiers

PMID30701169
PMCPMC6343460
OpenAlexW2909865072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.