Evidence map›Paper›PMID 30700984›Full record

ArticleFrontiers in microbiology2018

Antibody Responses to Antigenic Targets of Recent Exposure Are Associated With Low-Density Parasitemia in Controlled Human

Lotus L van den Hoogen, Jona Walk, Tate Oulton, Isaie J Reuling, Linda Reiling, James G Beeson, Ross L Coppel, Susheel K Singh, Simon J Draper, Teun Bousema and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
6.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 4 countries.

Lotus L van den HoogenDepartment of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Jona WalkDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands.
Tate OultonDepartment of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Isaie J ReulingDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands.
Linda ReilingBurnet Institute, Melbourne, VIC, Australia.
James G BeesonBurnet Institute, Melbourne, VIC, Australia.
Ross L CoppelDepartment of Microbiology, Monash University, Clayton, VIC, Australia.
Susheel K SinghDepartment of Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.
Simon J DraperJenner Institute, University of Oxford, Oxford, United Kingdom.
Teun BousemaDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands.
Chris DrakeleyDepartment of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, United Kingdom.
Robert SauerweinDepartment of Medical Microbiology, Radboud University Medical Center, Nijmegen, Netherlands.
Kevin K A TettehDepartment of Immunology and Infection, London School of Hygiene & Tropical Medicine, London, United Kingdom.
London School of Hygiene & Tropical Medicine · GBRadboud University Medical Center · NLRadboud University Nijmegen · NLBurnet Institute · AUMonash University · AUStatens Serum Institut · DKUniversity of Melbourne · AUUniversity of Oxford · GB

Funding

Medical Research Council MR/K025554/1Wellcome Trust 091924
6 · The paper itself

Abstract

The majority of malaria infections in low transmission settings remain undetectable by conventional diagnostics. A powerful model to identify antibody responses that allow accurate detection of recent exposure to low-density infections is controlled human malaria infection (CHMI) studies in which healthy volunteers are infected with the

Indexed as

antibodiescontrolled human malaria infection (CHMI)exposuremalariasero-epidemiologysero-surveillance

Identifiers

PMID30700984
PMCPMC6343524
OpenAlexW2909719891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.