Evidence map›Paper›PMID 30700972›Full record

ArticleHereditas2019

A new model of the mechanism underlying lead poisoning: SNP in miRNA target region influence the AGT expression level.

Yu Wu, Miaomiao Wang, Jinlong Zhang, Na Sun, Chunping Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hereditas, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. No Association BetweenDiabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  4. Article
  5. Genetic Variations inJournal of clinical medicine · 2023
    Article
  6. Article
  7. Novel Direction in Mechanisms Underlying Lead Toxicity: Evidence and Prospective.Indian journal of clinical biochemistry : IJCB · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Yu Wu *1Wuxi Medical School, Jiangnan University, 499 Jincheng Rd, Wuxi, 214023 People's Republic of China.
Miaomiao Wang *Department of Occupational Health, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Jinlong ZhangDepartment of Occupational Health, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Na SunDepartment of Occupational Health, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Chunping LiDepartment of Occupational Health, Wuxi Center for Disease Control and Prevention, Wuxi, China.
Jiangnan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo determine if the rs7079 polymorphism located in the 3' UTR of the angiotensinogen gene (

resultsSerum AGT levels were significantly higher in individuals carrying the rs7079 CA genotype, as compared to those carrying the rs7079 CC genotype. The binding of the miRNA mimics miR-31-5p and miR-584-5p to the 3' UTR of

conclusionsThe rs7079 C to A substitution reduced the binding of miR-31-5p/miR-584-5p to the 3' UTR of

Indexed as

3' Untranslated RegionsAdultAngiotensinogenCase-Control StudiesFemaleGenotypeHumansLead PoisoningMaleMicroRNAsMiddle AgedPolymorphism, GeneticYoung Adult3' Untranslated RegionsAngiotensinogenMicroRNAsMIRN31 microRNA, humanMIRN584 microRNA, human3′ untranslated region (3′ UTR)AGTLead poisoningmiRNASNP

Identifiers

PMID30700972
PMCPMC6348078
OpenAlexW2921618882

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.