Evidence map›Paper›PMID 30700937›Full record

ReviewWorld journal of gastroenterology2019

Human immunodeficiency virus and hepatotropic viruses co-morbidities as the inducers of liver injury progression.

Murali Ganesan, Larisa Y Poluektova, Kusum K Kharbanda, Natalia A Osna

Open access · hybridAbstract readReview
In one paragraph

Review in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 1 synthesis or guideline pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Liver disease in people living with HIV infection: a changing landscape.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. YAP mediates HIV-related liver fibrosis.JHEP reports : innovation in hepatology · 2024
    Article
  12. Article
  13. Article
  14. Renal Manifestations of Chronic Hepatitis C: A Review.Journal of clinical medicine · 2024
    Review
  15. Article
  16. Article
  17. [Delta hepatitis in Africa: epidemiological and clinical particularities].Medecine tropicale et sante internationale · 2023
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Murali GanesanResearch Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
Larisa Y PoluektovaDepartment of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, United States.
Kusum K KharbandaResearch Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
Natalia A OsnaResearch Service, Veterans Affairs Nebraska-Western Iowa Health Care System, Omaha, NE 68105, United States.
University of Nebraska Medical Center · USVA Nebraska Western Iowa Health Care System · US

Funding

Center for Humanized MiceR24OD018546 · OD · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GORANTLA, SANTHI, POLUEKTOVA, LARISA Y · 2014 to 2017
$3.2M
Ethanol suppresses HBV peptide-MHC Class I presentation on hepatocytesK01AA026864 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI GANESAN, MURALI · 2018 to 2022
$684k
NIAAA NIH HHS K01 AA026864NIH HHS R24 OD018546
6 · The paper itself

Abstract

Hepatotropic viruses induced hepatitis progresses much faster and causes more liver- related health problems in people co-infected with human immunodeficiency virus (HIV). Although treatment with antiretroviral therapy has extended the life expectancy of people with HIV, liver disease induced by hepatitis B virus (HBV) and hepatitis C virus (HCV) causes significant numbers of non-acquired immune deficiency syndrome (AIDS)-related deaths in co-infected patients. In recent years, new insights into the mechanisms of accelerated fibrosis and liver disease progression in HIV/HCV and HIV/HBV co-infections have been reported. In this paper, we review recent studies examining the natural history and pathogenesis of liver disease in HIV-HCV/HBV co-infection in the era of direct acting antivirals (DAA) and antiretroviral therapy (ART). We also review the novel therapeutics for management of HIV/HCV and HIV/HBV co-infected individuals.

Indexed as

Antiviral AgentsCoinfectionComorbidityDisease ProgressionDrug Therapy, CombinationHepacivirusHepatitis BHepatitis B virusHepatitis CHIVHIV InfectionsHumansLiverAntiviral AgentsFibrosisHepatitis B virusHepatitis C virusHuman immunodeficiency virusStiffnessTreatment

Identifiers

PMID30700937
PMCPMC6350175
OpenAlexW2913611168

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.