ArticleLaboratory investigation; a journal of technical methods and pathology2019
Knockout of α-calcitonin gene-related peptide attenuates cholestatic liver injury by differentially regulating cellular senescence of hepatic stellate cells and cholangiocytes.
Erratum issuedOpen access · bronzeAbstract read
In one paragraph
Article in Laboratory investigation; a journal of technical methods and pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
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- Mapping the evolution of liver aging research: A bibliometric analysis.World journal of gastroenterology · 2024Article
- Regulation of intestinal senescence during cholestatic liver disease modulates barrier function and liver disease progression.JHEP reports : innovation in hepatology · 2024Article
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- Hypervigilance, Allostatic Load, and Migraine Prevention: Antibodies to CGRP or Receptor.Neurology and therapy · 2021Review
- Mast Cells Induce Ductular Reaction Mimicking Liver Injury in Mice Through Mast Cell-Derived Transforming Growth Factor Beta 1 Signaling.Hepatology (Baltimore, Md.) · 2021Article
- It's all about the spaces between cells: role of extracellular matrix in liver fibrosis.Annals of translational medicine · 2021Review
- Knockout of the Tachykinin Receptor 1 in the Mdr2The American journal of pathology · 2020Article
- Concise Review: Functional Roles and Therapeutic Potentials of Long Non-coding RNAs in Cholangiopathies.Frontiers in medicine · 2020Review
- Knockdown of vimentin reduces mesenchymal phenotype of cholangiocytes in the Mdr2EBioMedicine · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
17 authors at 8 institutions in 3 countries.
Ying WanDepartment of Pathophysiology, Southwest Medical University, Luzhou, 646000, China.
Ludovica CeciDepartment of Medical Physiology, Texas A&M University Health Science Center, Temple, TX, USA.
Nan WuDepartment of Medical Physiology, Texas A&M University Health Science Center, Temple, TX, USA.
Tianhao ZhouDepartment of Medical Physiology, Texas A&M University Health Science Center, Temple, TX, USA.
Lixian ChenDepartment of Medical Physiology, Texas A&M University Health Science Center, Temple, TX, USA.
Julie VenterDepartment of Medical Physiology, Texas A&M University Health Science Center, Temple, TX, USA.
Heather FrancisDepartment of Medical Physiology, Texas A&M University Health Science Center, Temple, TX, USA.
Francesca BernuzziHumanitas Clinical and Research Center, Rozzano (MI), Italy.
Pietro InvernizziHumanitas Clinical and Research Center, Rozzano (MI), Italy.ORCID 0000-0003-3262-1998
Konstantina KyritsiDepartment of Medical Physiology, Texas A&M University Health Science Center, Temple, TX, USA.
Paul BakerDepartment of Medical Physiology, Texas A&M University Health Science Center, Temple, TX, USA.
Qiaobing HuangDepartment of Pathophysiology, Key Lab for Shock and Microcirculation Research of Guangdong Province, Southern Medical University, Guangzhou, China.
Chaodong WuDepartment of Nutrition and Food Science, Texas A&M University, College Station, TX, 77843, USA.
Amelia SybengaDepartment of Pathology, Microbiology, and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA.
Gianfranco AlpiniDepartment of Medical Physiology, Texas A&M University Health Science Center, Temple, TX, USA. gialpini@iu.edu.
Fanyin MengDepartment of Medical Physiology, Texas A&M University Health Science Center, Temple, TX, USA.
Shannon GlaserDepartment of Medical Physiology, Texas A&M University Health Science Center, Temple, TX, USA.
Texas A&M University · USCentral Texas Veterans Health Care System · USHumanitas University · ITBaylor Scott & White Health · USSouthern Medical University · CNSouthwest Medical University · CNTemple College · USVanderbilt University · US
Funding
GROWTH REGULATION OF THE INTRAHEPATIC BILIARY TREER01DK054811 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2000 to 2021
$3.8MThe Paracrine Regulation of Mast Cells During Biliary/Cholangiocyte Repair and DamageR01DK108959 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI FRANCIS, HEATHER L · 2016 to 2024
$2.5MRegulation of Bile Duct Growth in Bile Duct Ligated RatsR01DK062975 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2005 to 2014
$1.9MRole of Sensory Neuropeptides in the Regulation of Biliary FunctionR01DK076898 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2008 to 2016
$1.8MTOWARD THE OPTIMAL TIMING OF INITIATION OF DIALYSISR01DK058411 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI CHERTOW, GLENN MATTHEW · 2001 to 2003
$1.8MThe Role of Stem Cell Derived Microvesicles in Cholestatic Liver InjuryR01DK107310 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2015 to 2019
$1.7MNeuroendocrine Regulation of Biliary Growth and FibrosisR01DK110035 · NIDDK · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, GLASER, SHANNON STROUD · 2017 to 2020
$1.2MFMRI and TMS Analysis of Frontal Lobes in AgingK01AG025157 · NIA · STANFORD UNIVERSITY · PI ROSEN, ALLYSON C · 2005 to 2009
$637kREGULATION OF CELLULAR SENESCENCE BY NON-CODING RNAS IN ALCOHOLIC LIVER INJURYR21AA025997 · NIAAA · SCOTT AND WHITE MEMORIAL HOSPITAL · PI ALPINI, GIANFRANCO D, MENG, FANYIN · 2017 to 2018
$435kRole of stem cell derived microvesicles in alcoholic liver injuryR21AA025157 · NIAAA · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI ALPINI, GIANFRANCO D, MENG, FANYIN · 2017 to 2018
$350kBLR&D Research Career Scientist AwardIK6BX004601 · VA · RLR VA MEDICAL CENTER · PI ALPINI, GIANFRANCO D · 2019 to 2025
–Mechanisms of synergistic regulation of biliary inflammation and fibrosisI01BX003031 · VA · RLR VA MEDICAL CENTER · PI FRANCIS, HEATHER L · 2016 to 2023
–BLRD VA I01 BX000574BLRD VA I01 BX001724BLRD VA I01 BX003031BLRD VA IK6 BX004601NIAAA NIH HHS R21 AA025157NIAAA NIH HHS R21 AA025997NIDDK NIH HHS R01 DK054811NIDDK NIH HHS R01 DK058411NIDDK NIH HHS R01 DK062975NIDDK NIH HHS R01 DK076898NIDDK NIH HHS R01 DK107310NIDDK NIH HHS R01 DK108959NIDDK NIH HHS R01 DK110035
Abstract
α-Calcitonin gene-related peptide (α-CGRP) is a 37-amino acid neuropeptide involved in several pathophysiological processes. α-CGRP is involved in the regulation of cholangiocyte proliferation during cholestasis. In this study, we aimed to evaluate if α-CGRP regulates bile duct ligation (BDL)-induced liver fibrosis by using a α-CGRP knockout (α-CGRP
Indexed as
AnimalsCalcitonin Gene-Related PeptideCase-Control StudiesCellular SenescenceCholangitis, SclerosingFemaleHepatic Stellate CellsHumansLiver CirrhosisMaleMAP Kinase Signaling SystemMice, Inbred C57BLMice, KnockoutCalcitonin Gene-Related Peptide
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.