Evidence map›Paper›PMID 30700810›Full record

ArticleScientific reports2019

Depletion of B cell-activating factor attenuates hepatic fat accumulation in a murine model of nonalcoholic fatty liver disease.

Yoshiko Nakamura, Masanori Abe, Keitarou Kawasaki, Teruki Miyake, Takao Watanabe, Osamu Yoshida, Masashi Hirooka, Bunzo Matsuura, Yoichi Hiasa

Abstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
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  5. Review
  6. Article
  7. Thermotherapy has Sexually Dimorphic Responses in APP/PS1 Mice.bioRxiv : the preprint server for biology · 2024
    Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Blocking BAFF Alleviates Hepatic Fibrosis inPathogens (Basel, Switzerland) · 2023
    Article
  13. Article
  14. Review
  15. Review
  16. Role of B Lymphocytes in the Pathogenesis of NAFLD: A 2022 Update.International journal of molecular sciences · 2022
    Review
  17. Review
  18. Review
  19. Pathogenesis from Inflammation to Cancer in NASH-Derived HCC.Journal of hepatocellular carcinoma · 2022
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yoshiko NakamuraDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.
Masanori AbeDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan. masaben@m.ehime-u.ac.jp.
Keitarou KawasakiDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.
Teruki MiyakeDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.
Takao WatanabeDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.
Osamu YoshidaDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.
Masashi HirookaDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.
Bunzo MatsuuraDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.
Yoichi HiasaDepartment of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, 791-0295, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity-induced adipose-tissue dysfunction is a critical contributor to the pathogenesis of nonalcoholic fatty liver disease (NAFLD). B cell-activating factor (BAFF) is an adipokine related to impaired insulin sensitivity, and the serum BAFF concentration is associated with NAFLD severity. In this study, we aimed to determine the direct in vivo role of BAFF in the development of insulin resistance, adipocyte dysfunction, and hepatic steatosis using BAFF

Indexed as

AdiposityAdipose TissueAnimalsB-Cell Activating FactorDiet, High-FatDisease Models, AnimalDown-RegulationFibrosisGlucose IntoleranceHepatocytesInflammationInsulin ResistanceLipidsLiverMaleMice, Inbred C57BLB-Cell Activating FactorLipidsTnfsf13b protein, mouse

Identifiers

PMID30700810
PMCPMC6353938

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.