ArticleScientific reports2019
Hyperuricemia Predicts an Early Decline in Renal Function among Older People: A Community-Based Cohort Study.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 21 citations in OpenAlex.
- Longitudinal serum uric acid transition patterns and their clinical, genetic, and dietary determinants: prospective prediction of incident hyperuricemia and gout in a Korean population-based cohort.Clinical rheumatology · 2026Article
- Association between uric acid to high-density lipoprotein cholesterol ratio and diabetic kidney disease in US adults.Scientific reports · 2025Article
- Predicting rapid kidney function decline in middle-aged and elderly Chinese adults using machine learning techniques.BMC medical informatics and decision making · 2025Article
- Approximation of Glomerular Filtration Rate after 1 Year Using Annual Medical Examination Data.Journal of clinical medicine · 2024Article
- Relationship of Serum Uric Acid with Kidney Function Decline Mediated by Systemic Arterial Stiffness: A Retrospective Cohort Study in Japan.Diagnostics (Basel, Switzerland) · 2024Article
- Sepsis and the Risks of Long-Term Renal Adverse Outcomes in Patients With Chronic Kidney Disease.Frontiers in medicine · 2022Article
- Association Between Kidney Function Decline and Baseline TNFR Levels or Change Ratio in TNFR by Febuxostat Chiefly in Non-diabetic CKD Patients With Asymptomatic Hyperuricemia.Frontiers in medicine · 2021Article
- Risk Factors for Chronic Kidney Disease in Older Adults with Hyperlipidemia and/or Cardiovascular Diseases in Taipei City, Taiwan: A Community-Based Cross-Sectional Analysis.International journal of environmental research and public health · 2020Article
- Association between lifestyle factors and decreased kidney function in older adults: a community-based cross-sectional analysis of the Taipei City elderly health examination database.BMC nephrology · 2020Article
- Impact of monocyte to high-density lipoprotein ratio on prevalent hyperuricemia: findings from a rural Chinese population.Lipids in health and disease · 2020Article
- Association of serum uric acid with visceral, subcutaneous and hepatic fat quantified by magnetic resonance imaging.Scientific reports · 2020Article
- Hyperuricemia as a Risk Factor for Atrial Fibrillation Due to Soluble and Crystalized Uric Acid.Circulation reports · 2019Review
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whether elevated serum uric acid levels (SUA) predict renal dysfunction remains controversial in the elderly. Therefore, we investigated the association between SUA and early renal function decline defined as an estimated glomerular filtration rate (eGFR) reduction ≥30% over 2 years. From 2001 to 2010, we conducted a longitudinal cohort study comprising 44,078 participants aged ≥65 years in the Taipei City Elderly Health Examination Database. Participants were classified by 1-mg/dL increment of SUA. We used multivariable logistic and Cox regression analyses to compare the risk of early renal function decline in different SUA groups. Compared to the reference SUA group of 5.0-5.9 mg/dL, hyperuricemic participants had increased risks of eGFR decline, starting at SUA ≥6.0 mg/dL (adjusted odds ratio [aOR] = 1.21, 95% confidence interval [CI] = 1.00-1.45). The risk progressively elevated as SUA increased, with the highest in the SUA ≥10.0 mg/dL group (aOR = 3.20, CI = 2.39-4.28). Multivariable Cox regression further confirmed that hyperuricemia was 1.12-fold (CI = 1.03-1.22, SUA ≥6.0 mg/dL) to 1.6-fold (CI = 1.37-1.86, SUA ≥10.0 mg/dL) more likely to develop early eGFR decline. Hyperuricemia-associated increased risks for early eGFR decline were consistent across subgroup and sensitivity analyses. Collectively, SUA ≥6.0 mg/dL independently predicted early renal dysfunction with eGFR decline ≥30% over 2 years in older people.
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