ArticleNature communications2019
The cholesterol biosynthesis pathway regulates IL-10 expression in human Th1 cells.
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Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
17.7field-weighted citation impact, top 1% of its field
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Who cites it
86 citing papers in PubMed, 132 citations in OpenAlex.
- Immune Consequences of Metabolic Syndrome and Its Treatment: A Cytokine Perspective.Immunology · 2026Article
- LDL receptor-mediated lipoprotein uptake fuels human CD4+ T cell polarization toward a c-MAF/IL-10- and FOXP3-driven phenotype.JCI insight · 2026Article
- Natural products as HMG-CoA reductase inhibitors (statins) for the management of non-communicable diseases.Inflammopharmacology · 2026Review
- Relationships Between Circulating Lipids, Lipoproteins, and Lymphocyte Subsets in the Multi-Ethnic Study of Atherosclerosis.Global heart · 2026Article
- Peroxisomal ABCD1 deficiency in mice drives Th1 bias through 25-HC-LXR signaling in CD4Frontiers in immunology · 2026Article
- Dynamic regulatory mechanism of cholesterol 25-hydroxylase-mediated antiviral response in RNA virus infections.Frontiers in cellular and infection microbiology · 2026Review
- Risk factors associated with return sepsis admission following emergency department discharge with infection.The American journal of emergency medicine · 2025Article
- Mechanisms of Interleukin-10-Mediated Immunosuppression in Viral Infections.Pathogens (Basel, Switzerland) · 2025Review
- ICOS regulates IL-10 production in group 2 innate lymphoid cells via cholesterol and cortisol biosynthesis.The Journal of clinical investigation · 2025Article
- Inside job: Roles of intracellular C3.The Journal of allergy and clinical immunology · 2025Review
- Bacteroides sphingolipids promote anti-inflammatory responses through the mevalonate pathway.Cell host & microbe · 2025Article
- An intracellular complement system drives metabolic and proinflammatory reprogramming of vascular fibroblasts in pulmonary hypertension.JCI insight · 2025Article
- Immunocyte lipid metabolic reprogramming: a novel pathway for targeted intervention in autoimmune diseases.Frontiers in immunology · 2025Review
- Recent advances in novel tumor immunotherapy strategies based on regulating the tumor microenvironment and immune checkpoints.Frontiers in immunology · 2025Review
- Chitinase-1 inhibition attenuates metabolic dysregulation and restores homeostasis in MASH animal models.Frontiers in immunology · 2025Article
- PCSK9 Manipulates Lipid Metabolism and the Immune Microenvironment in Cancer.OncoTargets and therapy · 2025Review
- The Utility of Synovial Fluid Interleukin-10 in Diagnosing Chronic Periprosthetic Joint Infection: A Prospective Cohort Study.Infection and drug resistance · 2025Article
- METTL3/miR-192-5p/SCD1 Axis Regulates Lipid Metabolism to Affect T Cell Differentiation in Asthma.Mediators of inflammation · 2025Article
- Immunometabolism in cancer: a systemic perspective.Frontiers in immunology · 2025Review
- Stearoyl-CoA desaturase in CD4Cell & bioscience · 2024Article
26 more citing papers are in PubMed but not listed here.
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Authors and funding
18 authors at 7 institutions in 6 countries.
Esperanza PeruchaAcademic Department of Rheumatology, King's College London, London, SE1 1UL, UK. esperanza.perucha@kcl.ac.uk.ORCID http://orcid.org/0000-0002-7802-0875
Rossella MelchiottiNational Institute for Health Research Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, SE1 9RT, UK.
Jack A BibbyAcademic Department of Rheumatology, King's College London, London, SE1 1UL, UK.
Wing WuAcademic Department of Rheumatology, King's College London, London, SE1 1UL, UK.
Klaus Stensgaard FrederiksenGlobal Drug Discovery, Novo Nordisk A/S, 2880, Bagsvaerd, Denmark.ORCID http://orcid.org/0000-0002-2725-1139
Ceri A RobertsDepartment of Inflammation Biology, School of Immunology and Microbial Sciences, Centre for Inflammation Biology and Cancer Immunology, King's College London, London, SE1 1UL, UK.
Zoe HallDepartment of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, Cambridge, CB2 1QW, UK.
Gaelle LeFriecMRC Centre for Transplantation, King's College London, London, SE1 9RT, UK.
Kevin A RobertsonDivision of Infection and Pathway Medicine, University of Edinburgh, Edinburgh, EH16 4SB, UK.
Paul LavenderSchool of Immunology and Microbial Sciences, King's College London, London, SE1 9RT, UK.
Jens Gammeltoft GerwienGlobal Drug Discovery, Novo Nordisk A/S, 2880, Bagsvaerd, Denmark.
Leonie S TaamsDepartment of Inflammation Biology, School of Immunology and Microbial Sciences, Centre for Inflammation Biology and Cancer Immunology, King's College London, London, SE1 1UL, UK.ORCID http://orcid.org/0000-0002-9337-7194
Julian L GriffinDepartment of Biochemistry and the Cambridge Systems Biology Centre, University of Cambridge, Cambridge, CB2 1QW, UK.
Emanuele de RinaldisNational Institute for Health Research Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust and King's College London, London, SE1 9RT, UK.
Lisa G M van BaarsenAmsterdam Rheumatology and immunology Center (ARC), Department of Rheumatology and Clinical Immunology, Amsterdam UMC, University of Amsterdam, 1105 AZ, Amsterdam, Netherlands.
Claudia KemperMRC Centre for Transplantation, King's College London, London, SE1 9RT, UK.
Peter GhazalDivision of Infection and Pathway Medicine, University of Edinburgh, Edinburgh, EH16 4SB, UK.
Andrew P CopeAcademic Department of Rheumatology, King's College London, London, SE1 1UL, UK. andrew.cope@kcl.ac.uk.ORCID http://orcid.org/0000-0003-0470-1827
King's College London · GBNovo Nordisk (Denmark) · DKUniversity of Cambridge · GBAmsterdam University Medical Centers · NLCardiff University · GBNHS Blood and Transplant · GBUniversity of Edinburgh · GB
Funding
The role of the intracellular complement system - the complosome - in Th1 biologyZIAHL006223 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI KEMPER, CLAUDIA · 2017 to 2025
$16.9MNCI CLINICAL INVESTIGATOR AWARD PROGRAMK08CA001006 · NCI · UNIVERSITY OF WISCONSIN MADISON · PI MERRITT, JAMES A · 1985 to 1985
–Chief Scientist Office ETM/202Medical Research Council G1002165Medical Research Council MC_PC_13030Medical Research Council MC_UP_A090_1006Medical Research Council MR/P011705/1Medical Research Council MR/P01836X/1
Abstract
The mechanisms controlling CD4
Indexed as
AtorvastatinCholesterolHumansHydroxycholesterolsInterferon-gammaInterleukin-10Th1 Cells25-hydroxycholesterolAtorvastatinCholesterolHydroxycholesterolsIL10 protein, humanInterferon-gammaInterleukin-10
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.