Evidence map›Paper›PMID 30700699›Full record

ArticleTranslational psychiatry2019

Increased cortical reactivity to repeated tones at 8 months in infants with later ASD.

Anna Kolesnik, Jannath Begum Ali, Teodora Gliga, Jeanne Guiraud, Tony Charman, Mark H Johnson, Emily J H Jones, BASIS Team

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Prediction in Autism Spectrum Disorder: A Systematic Review of Empirical Evidence.Autism research : official journal of the International Society for Autism Research · 2021
    Pooled it
  3. Pooled it
  4. Retinal GABAergic Alterations in Adults with Autism Spectrum Disorder.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Trial
  5. Trial
  6. Review
  7. Article
  8. Receptive-Expressive Language Phenotypes in Infants and Toddlers With Autism Features.Autism research : official journal of the International Society for Autism Research · 2026
    Article
  9. Review
  10. Article
  11. Review
  12. Infant sensory gating and a developmental cascade to autistic traits and anxiety.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna KolesnikCentre for Brain and Cognitive Development, Birkbeck, University of London, London, UK. akoles01@mail.bbk.ac.uk.
Jannath Begum AliCentre for Brain and Cognitive Development, Birkbeck, University of London, London, UK.
Teodora GligaCentre for Brain and Cognitive Development, Birkbeck, University of London, London, UK.
Jeanne GuiraudCore CAMHS (Child and Adolescent Mental Health Service), Brookside Family Consultation Clinic, Cambridge, UK.
Tony CharmanPsychology Department, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.ORCID http://orcid.org/0000-0003-1993-6549
Mark H JohnsonDepartment of Psychology, University of Cambridge, Cambridge, UK.
Emily J H JonesCentre for Brain and Cognitive Development, Birkbeck, University of London, London, UK. e.jones@bbk.ac.uk.
BASIS Team

Funding

Medical Research Council G0701484Medical Research Council MR/K021389/1Wellcome Trust
6 · The paper itself

Abstract

Dysregulation of cortical excitation/inhibition (E/I) has been proposed as a neuropathological mechanism underlying core symptoms of autism spectrum disorder (ASD). Determining whether dysregulated E/I could contribute to the emergence of behavioural symptoms of ASD requires evidence from human infants prior to diagnosis. In this prospective longitudinal study, we examine differences in neural responses to auditory repetition in infants later diagnosed with ASD. Eight-month-old infants with (high-risk: n = 116) and without (low-risk: n = 27) an older sibling with ASD were tested in a non-linguistic auditory oddball paradigm. Relative to high-risk infants with typical development (n = 44), infants with later ASD (n = 14) showed reduced repetition suppression of 40-60 Hz evoked gamma and significantly greater 10-20 Hz inter-trial coherence (ITC) for repeated tones. Reduced repetition suppression of cortical gamma and increased phase-locking to repeated tones are consistent with cortical hyper-reactivity, which could in turn reflect disturbed E/I balance. Across the whole high-risk sample, a combined index of cortical reactivity (cortical gamma amplitude and ITC) was dimensionally associated with reduced growth in language skills between 8 months and 3 years, as well as elevated levels of parent-rated social communication symptoms at 3 years. Our data show that cortical 'hyper-reactivity' may precede the onset of behavioural traits of ASD in development, potentially affecting experience-dependent specialisation of the developing brain.

Indexed as

Social BehaviorAcoustic StimulationAutism Spectrum DisorderCerebral CortexFemaleHumansInfantLongitudinal StudiesMagnetic Resonance ImagingMaleProspective Studies

Identifiers

PMID30700699
PMCPMC6353960

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.