ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2019
Subthalamic Nucleus and Sensorimotor Cortex Activity During Speech Production.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 62 citations in OpenAlex.
- A machine learning-derived speech index as a biomarker for Huntington's disease severity.Journal of neurology · 2026Article
- Distinct Temporal Patterns of Human Neural Firing in the Subthalamic Nucleus During Speech and Orofacial Movement.bioRxiv : the preprint server for biology · 2025Article
- Dissociation between Simple and Complex Speech Motor Tasks within the Bilateral Motor Thalamus.eNeuro · 2025Article
- Long-term consistency of aperiodic and periodic physiomarkers in subthalamic local field potentials in Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Spike-phase coupling of subthalamic neurons to posterior perisylvian cortex predicts speech sound accuracy.Nature communications · 2025Article
- Whole-brain dynamics of articulatory, acoustic and semantic speech representations.Communications biology · 2025Article
- Subthalamic nucleus neurons encode syllable sequence and phonetic characteristics during speech.Journal of neurophysiology · 2024Article
- Acoustic assessment in mandarin-speaking Parkinson's disease patients and disease progression monitoring and brain impairment within the speech subsystem.NPJ Parkinson's disease · 2024Review
- Subthalamic nucleus-language network connectivity predicts dopaminergic modulation of speech function in Parkinson's disease.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A supervised data-driven spatial filter denoising method for speech artifacts in intracranial electrophysiological recordings.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Lateralization and Time-Course of Cortical Phonological Representations during Syllable Production.eNeuro · 2023Article
- Closed-Loop Adaptive Deep Brain Stimulation in Parkinson's Disease: Procedures to Achieve It and Future Perspectives.Journal of Parkinson's disease · 2023Review
- Lexicality-Modulated Influence of Auditory Cortex on Subthalamic Nucleus During Motor Planning for Speech.Neurobiology of language (Cambridge, Mass.) · 2023Article
- Cortical metabolic characteristics of anti-leucine-rich glioma-inactivated 1 antibody encephalitis based onFrontiers in neurology · 2023Article
- Differentiation of speech-induced artifacts from physiological high gamma activity in intracranial recordings.NeuroImage · 2022Article
- Articulatory Gain Predicts Motor Cortex and Subthalamic Nucleus Activity During Speech.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Article
- Motor constellation theory: A model of infants' phonological development.Frontiers in psychology · 2022Article
- Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, interventional psychiatry, and women in neuromodulation.Frontiers in human neuroscience · 2022Article
- Simultaneously recorded subthalamic and cortical LFPs reveal different lexicality effects during reading aloud.Journal of neurolinguistics · 2021Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 4 countries.
Funding
Abstract
The sensorimotor cortex is somatotopically organized to represent the vocal tract articulators such as lips, tongue, larynx, and jaw. How speech and articulatory features are encoded at the subcortical level, however, remains largely unknown. We analyzed LFP recordings from the subthalamic nucleus (STN) and simultaneous electrocorticography recordings from the sensorimotor cortex of 11 human subjects (1 female) with Parkinson's disease during implantation of deep-brain stimulation (DBS) electrodes while they read aloud three-phoneme words. The initial phonemes involved either articulation primarily with the tongue (coronal consonants) or the lips (labial consonants). We observed significant increases in high-gamma (60-150 Hz) power in both the STN and the sensorimotor cortex that began before speech onset and persisted for the duration of speech articulation. As expected from previous reports, in the sensorimotor cortex, the primary articulators involved in the production of the initial consonants were topographically represented by high-gamma activity. We found that STN high-gamma activity also demonstrated specificity for the primary articulator, although no clear topography was observed. In general, subthalamic high-gamma activity varied along the ventral-dorsal trajectory of the electrodes, with greater high-gamma power recorded in the dorsal locations of the STN. Interestingly, the majority of significant articulator-discriminative activity in the STN occurred before that in sensorimotor cortex. These results demonstrate that articulator-specific speech information is contained within high-gamma activity of the STN, but with different spatial and temporal organization compared with similar information encoded in the sensorimotor cortex.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.