Evidence map›Paper›PMID 30700454›Full record

ArticleBMJ case reports2019

Invasive aspergillosis complicating treatment with tyrosine kinase inhibitors.

Tajwar Nasir, Claudia Lee, Alexandra Sc Lawrence, Jeremy S Brown

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Tajwar NasirRespiratory Division of Medicine, University College London Medical School, London, UK.
Claudia LeeRespiratory Division of Medicine, University College London Medical School, London, UK.
Alexandra Sc LawrenceRespiratory Division of Medicine, University College London Hospital, London, UK.
Jeremy S BrownRespiratory Division of Medicine, University College London, London, UK.
University College London · GBUniversity College Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We describe three cases of pulmonary aspergillosis (PA) in three patients without traditional risk factors for invasive aspergillosis infection, such as prolonged neutropenia or high dose systemic corticosteroid therapy. All three patients developed PA while taking tyrosine kinase inhibitors (TKI) and sustained greater clinical improvement once TKI were withdrawn. Our case series supports the theory TKI treatment can increase susceptibility to PA without causing neutropenia. Recognition that TKI treatment may predispose to invasive aspergillosis will allow for rapid recognition of affected patients and more effective management of future cases.

Indexed as

AgedAntifungal AgentsAspergillosisFatal OutcomeFemaleGastrointestinal Stromal TumorsHumansInvasive Fungal InfectionsLeukemiaLungMaleMiddle AgedProtein Kinase InhibitorsTomography, X-Ray ComputedTreatment OutcomeAntifungal AgentsProtein Kinase Inhibitorsdrugs: respiratory systemhaematology (drugs and medicines)infectionsmalignant disease and immunosuppression

Identifiers

PMID30700454
PMCPMC6352846
OpenAlexW2911612063

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.