ArticleCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology2019
Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis.
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In one paragraph
Article in Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
2.0field-weighted citation impact, top 12% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.
- Revisiting the association between pretreatment thrombocytosis and cancer survival outcomes: an umbrella review of meta-analyses.BMC cancer · 2024Pooled it
- Systematic review of Mendelian randomization studies on risk of cancer.BMC medicine · 2022Pooled it
- Trial
- High Circulating Platelet Count as a Risk Factor for Lung Squamous Cell Carcinoma: A Retrospective Study and Mendelian Randomization Analysis.The clinical respiratory journal · 2025Article
- The Lung Is Not a Primary Site of Platelet Biogenesis.Physiological research · 2025Article
- Causal Analysis of Platelet Indices and Breast Cancer, Including Estrogen Receptor-Specific Subtypes: A Mendelian Randomization Study.International journal of women's health · 2025Article
- The causal association between neutrophil counts and the risk of lung cancer: a Mendelian randomization study.Journal of Cancer · 2025Article
- Association of baseline plasma D-dimer and platelets with progression-free survival in patients with stage IV non-small cell lung cancer treated with anti-PD-1 antibody.Translational lung cancer research · 2024Article
- Integrating Machine Learning and the SHapley Additive exPlanations (SHAP) Framework to Predict Lymph Node Metastasis in Gastric Cancer Patients Based on Inflammation Indices and Peripheral Lymphocyte Subpopulations.Journal of inflammation research · 2024Article
- Interactions of platelets with obesity in relation to lung cancer risk in the UK Biobank cohort.Respiratory research · 2023Article
- Pro-Tumorigenic and Thrombotic Activities of Platelets in Lung Cancer.International journal of molecular sciences · 2023Review
- Platelets in the tumor microenvironment and their biological effects on cancer hallmarks.Frontiers in oncology · 2023Review
- Non-small cell lung cancer in China.Cancer communications (London, England) · 2022Review
- A predictive model for advanced oropharyngeal cancer patients treated with chemoradiation.BMC cancer · 2022Article
- Association of colorectal cancer with genetic and epigenetic variation in PEAR1-A population-based cohort study.PloS one · 2022Article
- Mendelian randomization study of interleukin (IL)-1 family and lung cancer.Scientific reports · 2021Article
- Circulating platelets as liquid biopsy sources for cancer detection.Molecular oncology · 2021Review
- The association between thrombocytosis and subtype of lung cancer: a systematic review and meta-analysis.Translational cancer research · 2021Article
- Predictive and prognostic values of preoperative platelet parameters in patients with gynecological tumors.Journal of clinical laboratory analysis · 2020Article
- Prognosis Value of Platelet Counts, Albumin and Neutrophil-Lymphocyte Ratio of Locoregional Recurrence in Patients with Operable Head and Neck Squamous Cell Carcinoma.Cancer management and research · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
77 authors at 20 institutions in 14 countries.
Ying Zhu *Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Yongyue Wei *Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Ruyang Zhang *Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Xuesi DongDepartment of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, China.
Sipeng ShenDepartment of Environmental Health, Harvard School of Public Health, Boston, Massachusetts.
Yang ZhaoDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Jianling BaiDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Neil E CaporasoDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Maria Teresa LandiDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Bin ZhuDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Stephen J ChanockDivision of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
Fangyi GuDepartment of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
Stephen LamBritish Columbia Cancer Agency, Vancouver, British Columbia, Canada.
Ming-Sound TsaoUniversity Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Frances A ShepherdUniversity Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Adonina TardonUniversity of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.ORCID 0000-0001-5150-1209
Ana Fernández-SomoanoUniversity of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.ORCID 0000-0002-8135-9079
Guillermo Fernandez-TardonUniversity of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.ORCID 0000-0002-7680-158X
Chu ChenProgram in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Matthew J BarnettProgram in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Jennifer DohertyProgram in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington.
Stig E BojesenDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
Mattias JohanssonInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Paul BrennanInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
James D McKayInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Robert Carreras-TorresInternational Agency for Research on Cancer, World Health Organization, Lyon, France.
Thomas MuleyThoraxklinik at University Hospital Heidelberg, Heidelberg, Germany.
Angela RischTranslational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany.ORCID 0000-0002-8026-5505
Heunz-Erich WichmannResearch Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Heike BickeboellerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Germany.
Albert RosenbergerDepartment of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Germany.ORCID 0000-0001-7848-1332
Gad RennertDepartment of Community Medicine and Epidemiology, Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.ORCID 0000-0002-8512-068X
Walid SalibaDepartment of Community Medicine and Epidemiology, Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Susanne M ArnoldMarkey Cancer Center, University of Kentucky, Lexington, Kentucky.
John K FieldInstitute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0003-3951-6365
Michael P A DaviesInstitute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.ORCID 0000-0002-7609-4977
Michael W MarcusInstitute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Xifeng WuDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Yuanqing YeDepartment of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Lynne R WilkensEpidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii.
Olle MelanderFaculty of Medicine, Lund University, Lund, Sweden.
Jonas ManjerFaculty of Medicine, Lund University, Lund, Sweden.
Hans BrunnströmDepartment of Pathology, Lund University, Lund, Sweden.ORCID 0000-0001-7402-138X
Rayjean J HungLunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.
Geoffrey LiuLunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.
Yonathan BrhaneLunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.
Linda KachuriLunenfeld-Tanenbaum Research Institute, Sinai Health System, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-3226-4727
Angeline S AndrewDepartment of Epidemiology, Geisel School of Medicine, Hanover, New Hampshire.
Eric J DuellUnit of Nutrition and Cancer, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain.ORCID 0000-0001-5256-0163
Lambertus A KiemeneyRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.ORCID 0000-0002-2368-1326
Erik Hfm van der HeijdenRadboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, the Netherlands.ORCID 0000-0003-3596-518X
Aage HaugenNational Institute of Occupational Health, Oslo, Norway.
Shanbeh ZienolddinyNational Institute of Occupational Health, Oslo, Norway.
Vidar SkaugNational Institute of Occupational Health, Oslo, Norway.
Kjell GrankvistDepartment of Medical Biosciences, Umeå University, Umeå, Sweden.ORCID 0000-0003-4289-2097
Mikael JohanssonDepartment of Medical Biosciences, Umeå University, Umeå, Sweden.
Penella J WollDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom.ORCID 0000-0002-1118-0831
Angela CoxDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom.ORCID 0000-0002-5138-1099
Fiona TaylorDepartment of Oncology and Metabolism, University of Sheffield, Sheffield, United Kingdom.
Dawn M TeareSchool of Health and Related Research, University of Sheffield, England, United Kingdom.
Philip LazarusDepartment of Pharmaceutical Sciences, College of Pharmacy, Washington State University, Spokane, Washington.
Matthew B SchabathDepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida.ORCID 0000-0003-3241-3216
Melinda C AldrichDepartment of Thoracic Surgery, Division of Epidemiology, Vanderbilt University Medical Center, Nashville, Tennessee.
Richard S HoulstonThe Institute of Cancer Research, London, England.ORCID 0000-0002-5268-0242
John McLaughlinPublic Health Ontario, Toronto, Ontario, Canada.
Victoria L StevensAmerican Cancer Society, Inc., Atlanta, Georgia.ORCID 0000-0003-0259-4407
Hongbing ShenDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Zhibin HuDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Juncheng DaiDepartment of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China.
Christopher I AmosBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.ORCID 0000-0002-8540-7023
Younghun HanBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Dakai ZhuBiomedical Data Science, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire.
Gary E GoodmanSwedish Medical Group, Seattle, Washington.
Feng ChenDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China. fengchen@njmu.edu.cn dchris@hsph.harvard.edu.
David C ChristianiDepartment of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China. fengchen@njmu.edu.cn dchris@hsph.harvard.edu.ORCID 0000-0002-0301-0242
Center for Cancer Research · USCentre international de recherche sur le cancer · FRDartmouth College · USLunenfeld-Tanenbaum Research Institute · CAMassachusetts Department of Public Health · USUniversity of Sheffield · GBCape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAJiangsu Cancer Hospital · CNLund University · SENational Institute of Occupational Health · NOUniversidad de Oviedo · ESUniversity of Liverpool · GBCancer Center of Hawaii · USNanjing Health and Health Commission · CNNanjing Medical University · CNPrincess Margaret Cancer Centre · CARadboud University Nijmegen · NLTechnion – Israel Institute of Technology · ILThe University of Texas MD Anderson Cancer Center · USUniversity of Göttingen · DE
Funding
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6MTRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5MUNIVERSITY OF TEXAS--SPORE IN LUNG CANCERP50CA070907 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI HEYMACH, JOHN V., MINNA, JOHN D. · 1996 to 2024
$57.4MUniversity of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI GERTRAUD MASKARINEC · 1996 to 2026
$56.2MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MUniversity of Kentucky Markey Cancer Center Support Grant ECIA SupplementP30CA177558 · NCI · UNIVERSITY OF KENTUCKY · PI Bernard Mark Evers · 2013 to 2026
$38.3MUnderstanding Population Differences in Cancer: The MEC StudyU01CA164973 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI HAIMAN, CHRISTOPHER ALAN, LE MARCHAND, LOIC · 2015 to 2025
$37.4MTranslating Molecular and Clinical Data to Population Lung Cancer Risk AssessmentU19CA203654 · NCI · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Christopher I. Amos · 2017 to 2026
$23.7MGENETIC SUSCEPTIBILITY TO CANCER IN MULTIETHNIC COHORTSR01CA063464 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HENDERSON, BRIAN E · 2001 to 2005
$23.2MAlpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) StudyZIACP010195 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI ALBANES, DEMETRIUS · 2009 to 2025
$22.5MTHE ROLE OF CAL IN CIF-MEDIATED DEGRADATION OF CFTRP20RR018787 · NCRR · DARTMOUTH COLLEGE · PI GERBER, SCOTT · 2003 to 2011
$21.9MRecruitment and Data CollectionP01CA168530 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI LE MARCHAND, LOIC · 2012 to 2016
$19.9MCancer Research UK C1298/A8362Cancer Research UK C1298/A8780Cancer Research UK C18281/A19169NCATS NIH HHS UL1 TR000117NCATS NIH HHS UL1 TR000445NCI NIH HHS K07 CA172294NCI NIH HHS P01 CA033619NCI NIH HHS P01 CA168530NCI NIH HHS P20 CA090578NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA071789NCI NIH HHS P30 CA076292NCI NIH HHS P30 CA177558NCI NIH HHS P50 CA070907NCI NIH HHS P50 CA090578NCI NIH HHS P50 CA119997NCI NIH HHS R01 CA063464NCI NIH HHS R01 CA074386NCI NIH HHS R01 CA092824NCI NIH HHS R01 CA111703NCI NIH HHS R01 CA144034NCI NIH HHS R01 CA151989NCI NIH HHS R01 CA176568NCI NIH HHS R01 CA194393NCI NIH HHS R35 CA197449NCI NIH HHS U01 CA063464NCI NIH HHS U01 CA164973NCI NIH HHS U01 CA167462NCI NIH HHS U01 CA182876NCI NIH HHS U01 CA194393NCI NIH HHS U01 CA209414NCI NIH HHS U19 CA148127NCI NIH HHS U19 CA203654NCI NIH HHS UM1 CA164973NCI NIH HHS UM1 CA167462NCI NIH HHS UM1 CA182876NCRR NIH HHS P20 RR018787NCRR NIH HHS S10 RR025141NHGRI NIH HHS U01 HG004798NIDA NIH HHS R01 DA017932NIH HHS S10 OD025092World Health Organization 001
Abstract
backgroundPlatelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear.
methodsWe performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk.
resultsMultiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall non-small cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15-2.27;
conclusionsOur findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention. IMPACT: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.
Indexed as
Adenocarcinoma of LungBiomarkers, TumorBlood PlateletsCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellCase-Control StudiesGenetic Predisposition to DiseaseHumansLung NeoplasmsMendelian Randomization AnalysisPlatelet CountPolymorphism, Single NucleotidePrognosisRisk FactorsSmall Cell Lung CarcinomaBiomarkers, Tumor
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