Evidence map›Paper›PMID 30700420›Full record

ArticleBlood2019

MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells.

Julia Merkenschlager, Urszula Eksmond, Luca Danelli, Jan Attig, George R Young, Carla Nowosad, Pavel Tolar, George Kassiotis

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. CD4Frontiers in immunology · 2023
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. B cell-intrinsic TLR9 expression is protective in murine lupus.The Journal of clinical investigation · 2020
    Article
  16. Review
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Julia MerkenschlagerRetroviral Immunology.
Urszula EksmondRetroviral Immunology.
Luca DanelliRetroviral Immunology.
Jan AttigRetroviral Immunology.ORCID 0000-0002-2159-2880
George R YoungRetrovirus-Host Interactions, and.ORCID 0000-0002-1203-588X
Carla NowosadImmune Receptor Activation Laboratory, The Francis Crick Institute, London, United Kingdom; and.
Pavel TolarImmune Receptor Activation Laboratory, The Francis Crick Institute, London, United Kingdom; and.
George KassiotisRetroviral Immunology.
The Francis Crick Institute · GBImperial College London · GBUnit of Virus Host Cell Interactions · FR

Funding

Cancer Research UK FC001099Medical Research CouncilWellcome Trust FC001099
6 · The paper itself

Abstract

Best known for presenting antigenic peptides to CD4

Indexed as

Cell DifferentiationAnimalsAntigen PresentationB-LymphocytesBone MarrowBone Marrow CellsCD4-Positive T-LymphocytesCell Line, TumorDisease ProgressionDNA-Binding ProteinsFemaleHistocompatibility Antigens Class IIHomeodomain ProteinsLeukemia, B-CellLymphocyte ActivationMaleDNA-Binding ProteinsHistocompatibility Antigens Class IIHomeodomain ProteinsRAG-1 proteinRag2 protein, mouse

Identifiers

PMID30700420
PMCPMC6567521
OpenAlexW2911771113

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.