Evidence map›Paper›PMID 30700418›Full record

ArticleBlood2019

Regulation of globin-heme balance in Diamond-Blackfan anemia by HSP70/GATA1.

Sarah Rio, Marc Gastou, Narjesse Karboul, Raphaёl Derman, Thunwarat Suriyun, Hana Manceau, Thierry Leblanc, Jamel El Benna, Caroline Schmitt, Slim Azouzi and 10 more

Open access · bronzeAbstract read
In one paragraph

Article in Blood, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
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  11. Ribosome specialization by cancer-associated ribosomal protein mutations: progress made and open questions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  12. Review
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  15. Ribosome heterogeneity in development and disease.Frontiers in cell and developmental biology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 6 institutions in 2 countries.

Sarah RioINSERM U1149/ERL 8252, Inflammation Research Center, Paris, France.
Marc GastouLABEX GR-Ex, Paris, France.ORCID 0000-0003-3030-4809
Narjesse KarboulINSERM U1149/ERL 8252, Inflammation Research Center, Paris, France.
Raphaёl DermanINSERM U1149/ERL 8252, Inflammation Research Center, Paris, France.ORCID 0000-0001-9010-1080
Thunwarat SuriyunUnité Mixte de Recherche (UMR) 1163, Institut Imagine, Paris, France.
Hana ManceauINSERM U1149/ERL 8252, Inflammation Research Center, Paris, France.ORCID 0000-0003-4158-0964
Thierry LeblancAssistance Publique-Hôpitaux de Paris, Hôpital Robert Debré, service d'onco-hématologie pédiatrique, Paris, France.
Jamel El BennaINSERM U1149/ERL 8252, Inflammation Research Center, Paris, France.ORCID 0000-0001-5733-216X
Caroline SchmittINSERM U1149/ERL 8252, Inflammation Research Center, Paris, France.ORCID 0000-0001-5145-7260
Slim AzouziLABEX GR-Ex, Paris, France.ORCID 0000-0001-5519-4031
Jérome LarghéroUniversity Sorbonne Paris Cité, Paris 7 University, Paris, France.ORCID 0000-0003-2086-7448
Zoubida KarimINSERM U1149/ERL 8252, Inflammation Research Center, Paris, France.ORCID 0000-0002-3724-5592
Alejandra Macias-GarciaInstitute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA.ORCID 0000-0001-8904-8761
Jane-Jane ChenInstitute of Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA.ORCID 0000-0002-4372-6907
Olivier HermineUniversity Sorbonne Paris Cité, Paris Descartes University, Paris, France.ORCID 0000-0003-2574-3874
Geneviève CourtoisUniversity Sorbonne Paris Cité, Paris Descartes University, Paris, France.ORCID 0000-0001-6370-5575
Hervé PuyINSERM U1149/ERL 8252, Inflammation Research Center, Paris, France.ORCID 0000-0003-3362-2634
Laurent GouyaINSERM U1149/ERL 8252, Inflammation Research Center, Paris, France.ORCID 0000-0002-1326-7025
Narla MohandasRed Cell Physiology Laboratory, New York Blood Center, New York, NY; and.ORCID 0000-0003-2271-5296
Lydie Da CostaINSERM U1149/ERL 8252, Inflammation Research Center, Paris, France.ORCID 0000-0001-8806-6941
Inserm · FRDélégation Paris 5 · FRMassachusetts Institute of Technology · USAssistance Publique – Hôpitaux de Paris · FRInstitut des Maladies Génétiques Imagine · FRNew York Blood Center · US

Funding

YEAST MEMBRANE CYTOSKELETONP01DK032094 · NIDDK · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI NARLA, MOHANDAS · 1987 to 2021
$26.7M
NIDDK NIH HHS P01 DK032094
6 · The paper itself

Abstract

Diamond-Blackfan anemia (DBA) is a congenital erythroblastopenia that is characterized by a blockade in erythroid differentiation related to impaired ribosome biogenesis. DBA phenotype and genotype are highly heterogeneous. We have previously identified 2 in vitro erythroid cell growth phenotypes for primary CD34

Indexed as

Cell DifferentiationAnemia, Diamond-BlackfanCell ProliferationCells, CulturedErythroid CellsFemaleFollow-Up StudiesGATA1 Transcription FactorGlobinsHaploinsufficiencyHemeHSP70 Heat-Shock ProteinsHumansInfantInfant, NewbornMaleGATA1 protein, humanGATA1 Transcription FactorGlobinsHemeHSP70 Heat-Shock ProteinsRibosomal ProteinsRNA, Small Interfering

Identifiers

PMID30700418
PMCPMC6428670
OpenAlexW2914427349

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.