ArticleBMC genomics2019
Dynamic expression and functional analysis of circRNA in granulosa cells during follicular development in chicken.
Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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Who cites it
45 citing papers in PubMed, 92 citations in OpenAlex.
- Circular RNAs as regulators and biomarkers of mammalian ovarian ageing.GeroScience · 2026Review
- Identification of CircRNA-Related ceRNA Networks in the Longissimus Dorsi of Yaks at Different Developmental Stages.Animals : an open access journal from MDPI · 2026Article
- Article
- Research advances in intramuscular fat deposition and chicken meat quality: genetics and nutrition.Journal of animal science and biotechnology · 2025Review
- Article
- Sperm-Derived CircRNA-1572 Regulates Embryogenesis and Zygotic Genome Activation by Targeting CCNB2 via Bta-miR-2478-L-2.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- CircGRB14 Inhibits Proliferation and Promotes Apoptosis of Granulosa Cells in Chicken Follicle Selection Through Sponging miR-12264-3p and miR-6660-3p.International journal of molecular sciences · 2025Article
- Identifying insulin-responsive circRNAs in chicken pectoralis.BMC genomics · 2025Article
- Diaph1 knockout inhibits mouse primordial germ cell proliferation and affects gonadal development.Reproductive biology and endocrinology : RB&E · 2024Article
- Identification and Functional Analysis of circRNAs during Goat Follicular Development.International journal of molecular sciences · 2024Article
- High expression circRALGPS2 in atretic follicle induces chicken granulosa cell apoptosis and autophagy via encoding a new protein.Journal of animal science and biotechnology · 2024Article
- Circular RNA expression in turkey skeletal muscle satellite cells is significantly altered by thermal challenge.Frontiers in physiology · 2024Article
- Dynamic mRNA expression during chicken ovarian follicle development.G3 (Bethesda, Md.) · 2023Article
- Transcriptome Analysis of Granulosa Cells Reveals Regulatory Mechanisms Related to Chicken Follicle Development.Animals : an open access journal from MDPI · 2023Article
- Circular RNA as a Novel Regulator and Promising Biomarker in Polycystic Ovary Syndrome.Biomolecules · 2023Review
- Transcriptome RNA Sequencing Reveals That Circular RNAs Are Abundantly Expressed in Embryonic Breast Muscle of Duck.Veterinary sciences · 2023Article
- Interacting Networks of the Hypothalamic-Pituitary-Ovarian Axis Regulate Layer Hens Performance.Genes · 2023Review
- Regulatory effects of circular RNA on hypoxia adaptation in chicken embryos.Journal of animal science · 2023Article
- Circular RNAs are associated with the resistance to Newcastle disease virus infection in duck cells.Frontiers in veterinary science · 2023Article
- Unveiling the circRNA-Mediated Immune Responses of Western Honey Bee Larvae toInternational journal of molecular sciences · 2022Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCircular RNA (circRNA) is a type of noncoding RNA involved in a variety of biological processes, especially in post-transcriptional regulation. The granulosa cells of follicles play a determining role in ovarian development. However, the function of circRNA in chicken follicles is unclear. To better understand the molecular mechanism underlying follicular development and granulosa cell function, we performed a strategy of second-generation sequencing and linear RNA depletion for granulosa cells from small yellow follicles (SYF, 5-8 mm), the smallest hierarchal follicles (F6, 9-12 mm), and the largest hierarchal follicles (F1, ~ 40 mm).
resultsWe predicted a total of 11,642 circRNAs that distributed on almost all chromosomes. The majority of the splice lengths of circRNAs were 200-500 nt and mainly produced from intron and CDS regions. During follicle growth, differentially expressed (DE) circRNAs showed dynamic changes which were tissue- and stage-specific. The host genes of DE circRNAs were functionally enriched in GTPase activity and several pathways involved in reproduction. Moreover, bioinformatic prediction analysis for circRalGPS2 demonstrated that circRNAs from the same genes may share common miRNA to act as a sponge. The predicted target genes were enriched in various biological processes including cognition, cell communication, and regulation of signaling, and several pathways related to reproduction such as tight junction, oocyte meiosis, progesterone-mediated oocyte maturation, and GnRH signaling.
conclusionsThis study provides a starting point for further experimental investigations into chicken circRNAs and casts a light on the understanding of follicle development.
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