SynthesisInternational journal of environmental research and public health2019
The Association between Lead and Attention-Deficit/Hyperactivity Disorder: A Systematic Review.
Synthesis in International journal of environmental research and public health, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it, 78 citations in OpenAlex.
- Exploring the link between toxic metal exposure and ADHD: a systematic review of pb and hg.Journal of neurodevelopmental disorders · 2024Pooled it
- Effects of prenatal exposure to NOEnvironmental science and pollution research international · 2020Pooled it
- Particulate Matter Exposure and Attention-Deficit/Hyperactivity Disorder in Children: A Systematic Review of Epidemiological Studies.International journal of environmental research and public health · 2019Pooled it
- Lead soil contribution to dust loading in urban homes built before and after 1978, measured through a community academic partnership.Journal of exposure science & environmental epidemiology · 2026Article
- Trace Element Imbalances in ADHD: Hair Mineral Profiling via Synchrotron X-ray Fluorescence and Wavelength-Dispersive X-ray Fluorescence.Biological trace element research · 2026Article
- Blood Lead Concentrations and Depressive and Anxiety Symptoms in Childhood.JAMA network open · 2026Article
- The Beneficial Effect of Ononis natrix Against Pb-Induced Sensorimotor, Neurobehavioral, and Oxidative Stress Impairments in Mice Offspring during Gestation and Lactation.Biological trace element research · 2026Article
- A community-based participatory research program to identify lead exposure risks and community priorities.Discover social science and health · 2026Article
- Exposure to heavy metals and neuropsychological performance in children with and without attention deficit hyperactivity disorder (ADHD).Scientific reports · 2025Article
- Environmental lead risk in the 21st century.Communications earth & environment · 2025Review
- Cerebral Vascular Toxicity after Developmental Exposure to Arsenic (As) and Lead (Pb) Mixtures.Toxics · 2024Article
- A Multigenerational Model of Environmental Risk for Black, Indigenous, and People of Color (BIPOC) Children and Families.Environmental health perspectives · 2024Article
- The Health-Related and Learning Performance Effects of Air Pollution and Other Urban-Related Environmental Factors on School-Age Children and Adolescents-A Scoping Review of Systematic Reviews.Current environmental health reports · 2024Article
- Association between Mediterranean diet and metal mixtures concentrations in pregnant people from the New Hampshire Birth Cohort Study.The Science of the total environment · 2024Article
- Article
- Necessity of an Integrative Animal Model for a Comprehensive Study of Attention-Deficit/Hyperactivity Disorder.Biomedicines · 2023Review
- The Association between ADHD and Environmental Chemicals-A Scoping Review.International journal of environmental research and public health · 2022Article
- Human risk associated with the ingestion of artichokes grown in soils irrigated with water contaminated by potentially toxic elements, Junin, Peru.Saudi journal of biological sciences · 2021Article
- Connecting inorganic mercury and lead measurements in blood to dietary sources of exposure that may impact child development.World journal of methodology · 2021Review
- Aggregation Induced Emissive Luminogens for Sensing of Toxic Elements.ChemistryOpen · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The etiology of Attention-Deficit/Hyperactivity Disorder (ADHD) is complex and multifactorial. Although the development of ADHD symptoms remains to be elucidated, in recent years, epigenetic processes have emerged as candidate mechanisms. Lead is one of the most dangerous environmental pollutants, and it is suspected to be associated with ADHD. The aim of the present study was to review the epidemiological literature currently available on the relation between lead exposure and the diagnosis of ADHD. The PubMed and EMBASE databases were searched from 1 July 2018 up to 31 July 2018. The authors included observational studies (cohort, case⁻control and cross-sectional studies) published in English carried out on children within the last 5 years, measuring lead exposure and health outcomes related to ADHD. Seventeen studies met the inclusion criteria: 5 of these studies found no association between lead exposure and ADHD whereas the remaining 12 studies showed positive associations, even though not all of them were homogeneous in terms of exposure periods considered or ADHD diagnosis. To conclude, the evidence from the studies allowed us to establish that there is an association between lead and ADHD and that even low levels of lead raise the risk. However, there is still a lack of longitudinal studies about the relationship between lead exposure and the development of ADHD. Given the potential importance for public health, further research that includes the entire potential risk factors for ADHD in children must be encouraged.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.