Evidence map›Paper›PMID 30699966›Full record

ArticleInternational journal of molecular sciences2019

Graphene-Induced Osteogenic Differentiation Is Mediated by the Integrin/FAK Axis.

Han Xie, Tong Cao, Alfredo Franco-Obregón, Vinicius Rosa

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 72 citations in OpenAlex.

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  19. Visualization of integrin molecules by fluorescence imaging and techniques.Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Han XieFaculty of Dentistry, National University of Singapore, 9 Lower Kent Ridge Road, Singapore 119085, Singapore. xiehan512@foxmail.com.ORCID 0000-0002-5982-0981
Tong CaoFaculty of Dentistry, National University of Singapore, 9 Lower Kent Ridge Road, Singapore 119085, Singapore. dencaot@nus.edu.sg.
Alfredo Franco-ObregónDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, NUHS Tower Block, Level 8, IE Kent Ridge Road, Singapore 119228, Singapore. suraf@nus.edu.sg.ORCID 0000-0002-2514-1083
Vinicius RosaFaculty of Dentistry, National University of Singapore, 9 Lower Kent Ridge Road, Singapore 119085, Singapore. denvr@nus.edu.sg.ORCID 0000-0002-9203-7657
National University of Singapore · SG

Funding

Ministry of Education - Singapore Academic Research Fund Tier 1, R-221-000-091-112National University Health System, Singapore NUHS Open Collaborative Research Grant NUHS O-CRG 2016 Oct-25
6 · The paper itself

Abstract

Graphene is capable of promoting osteogenesis without chemical induction. Nevertheless, the underlying mechanism(s) remain largely unknown. The objectives here were: (i) to assess whether graphene scaffolds are capable of supporting osteogenesis in vivo and; (ii) to ascertain the participation of the integrin/FAK mechanotransduction axis during the osteogenic differentiation induced by graphene. MSC-impregnated graphene scaffolds (

Indexed as

AmidesAnimalsFocal Adhesion Protein-Tyrosine KinasesGraphiteIntegrinsMechanotransduction, CellularMesenchymal Stem CellsMiceMice, SCIDOsteogenesisPyrazolesPyridinesQuinolinesSignal TransductionTissue ScaffoldsAmidesDMH1 compoundFocal Adhesion Protein-Tyrosine KinasesGraphiteIntegrinsPyrazolesPyridinesQuinolinesY 27632bonedifferentiationfocal adhesion kinasemechanicalnanomaterialsosteoblasttissue engineering

Identifiers

PMID30699966
PMCPMC6387117
OpenAlexW2911308132

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.