Evidence map›Paper›PMID 30699923›Full record

ArticleViruses2019

Drug Repurposing Campaigns for Human Cytomegalovirus Identify a Natural Compound Targeting the Immediate-Early 2 (IE2) Protein: A Comment on "The Natural Flavonoid Compound Deguelin Inhibits HCMV Lytic Replication within Fibroblasts".

Beatrice Mercorelli, Anna Luganini, Giorgio Palù, Giorgio Gribaudo, Arianna Loregian

Open access · goldAbstract readComment
In one paragraph

Article in Viruses, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Beatrice MercorelliDepartment of Molecular Medicine, University of Padua, 35121 Padua, Italy. beatrice.mercorelli@unipd.it.ORCID 0000-0003-0654-8045
Anna LuganiniDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy. anna.luganini@unito.it.
Giorgio PalùDepartment of Molecular Medicine, University of Padua, 35121 Padua, Italy. giorgio.palu@unipd.it.
Giorgio GribaudoDepartment of Life Sciences and Systems Biology, University of Turin, 10123 Turin, Italy. giorgio.gribaudo@unito.it.ORCID 0000-0002-8900-861X
Arianna LoregianDepartment of Molecular Medicine, University of Padua, 35121 Padua, Italy. arianna.loregian@unipd.it.
University of Padua · ITUniversity of Turin · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus that establishes a lifelong persistence in the host through both chronic and latent states of infection [...].

Indexed as

Drug RepositioningCytomegalovirusFibroblastsFlavonoidsGene Expression Regulation, ViralHumansRotenoneVirus ReplicationdeguelinFlavonoidsRotenone

Identifiers

PMID30699923
PMCPMC6409840
OpenAlexW2912285443

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.