Evidence map›Paper›PMID 30699863›Full record

ArticleJournal of affective disorders2019

Negative peer social interactions and oxytocin levels linked to suicidal ideation in anxious youth.

Eli R Lebowitz, Hilary P Blumberg, Wendy K Silverman

Abstract read
In one paragraph

Article in Journal of affective disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Research Review: Pediatric anxiety disorders - what have we learnt in the last 10 years?Journal of child psychology and psychiatry, and allied disciplines · 2021
    Review
  7. Oxytocin Pathway Gene (Frontiers in psychiatry · 2021
    Article
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Eli R LebowitzChild Study Center, Yale School of Medicine, 230 S. Frontage Rd., New Haven, CT 06520, United States. Electronic address: eli.lebowitz@yale.edu.
Hilary P BlumbergChild Study Center, Yale School of Medicine, 230 S. Frontage Rd., New Haven, CT 06520, United States; Departments of Psychiatry and Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT 06520, United States.
Wendy K SilvermanChild Study Center, Yale School of Medicine, 230 S. Frontage Rd., New Haven, CT 06520, United States.
Yale University · US

Funding

Institutional Career Development CoreKL2TR001862 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$12.2M
Yale University Clinical and Translational Science Award ProgramKL2TR000140 · NCATS · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2012 to 2015
$2.9M
Brain response associated with parent-based treatment for childhood anxiety disordersR61MH115113 · NIMH · YALE UNIVERSITY · PI GEE, DYLAN GRACE, LEBOWITZ, ELI · 2018 to 2019
$1.5M
Explanatory Clinical Trial of a Novel Parent Intervention for Childhood AnxietyK23MH103555 · NIMH · YALE UNIVERSITY · PI LEBOWITZ, ELI · 2014 to 2017
$703k
Fibroblast Growth Factor 2's role in Fear and Approach Motivation in Anxious and Depressed Children and their MothersR21MH113946 · NIMH · YALE UNIVERSITY · PI LEBOWITZ, ELI, SILVERMAN, WENDY K. · 2017 to 2018
$461k
NCATS NIH HHS KL2 TR000140NCATS NIH HHS KL2 TR001862NIMH NIH HHS K23 MH103555NIMH NIH HHS R21 MH113946NIMH NIH HHS R61 MH115113
6 · The paper itself

Abstract

backgroundAnxious youth are at risk for negative peer interactions including peer victimization, and for suicidal ideation. However, data about the pattern of association between these two factors are scarce. In this study we examined the association between negative peer interactions and suicidal ideation in a sample of children and adolescents with anxiety disorders, and whether oxytocin, which has been shown to enhance the impact of social events, moderates the impact of negative peer interactions on suicidal ideation.

methodParticipants were 168 youths with primary anxiety disorders. All participants were assessed with semi-structured diagnostic interviews, and with self-report measures of suicidal ideation, negative peer interactions, anxiety, and depression. The anxious youths' salivary oxytocin levels were measured with immunoassay.

resultsThirty percent of the anxious youths reported suicidal ideation, with suicidal ideation severity associated with negative peer social interactions and depressive symptoms. Consistent with past data indicating that oxytocin enhances the impact of social events, the association between peer negative social interactions and suicidal ideation was stronger in youths with high oxytocin levels than in youths with low levels (i.e., moderation). LIMITATIONS: Assessment focused on suicidal ideation and data on suicidal behavior were not available. Limitations inherent to immunoassay measurement of peripheral oxytocin levels are noted.

conclusionNegative peer interactions are associated with suicidal ideation in youth with anxiety disorders, and the association is stronger in youth with high oxytocin levels.

Indexed as

Interpersonal RelationsPeer GroupSuicidal IdeationAdolescentAnxiety DisordersBullyingChildCrime VictimsDepressionFemaleHumansMaleOxytocinSalivaSelf ReportOxytocinAdolescentAnxietyChildOxytocinSuicidal ideation

Identifiers

PMID30699863
PMCPMC6361537
OpenAlexW2901884273

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.